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Vaccine-induced Antibodies Target Sequestered Viral Antigens to Prevent Ocular HSV-1 Pathogenesis, Preserve Vision, and Preempt Productive Neuronal Infection
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated va...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462227/ https://www.ncbi.nlm.nih.gov/pubmed/30670763 http://dx.doi.org/10.1038/s41385-019-0131-y |