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CRISPR-interference-based modulation of mobile genetic elements in bacteria

Spontaneous mutagenesis of synthetic genetic constructs by mobile genetic elements frequently results in the rapid loss of engineered functions. Previous efforts to minimize such mutations required the exceedingly time-consuming manipulation of bacterial chromosomes and the complete removal of inser...

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Detalles Bibliográficos
Autores principales:	Nyerges, Ákos, Bálint, Balázs, Cseklye, Judit, Nagy, István, Pál, Csaba, Fehér, Tamás
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462304/ https://www.ncbi.nlm.nih.gov/pubmed/31008359 http://dx.doi.org/10.1093/synbio/ysz008

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