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Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017

Children and adults residing in densely populated urban centers around the world are at risk of seasonal influenza-like illness caused by respiratory viruses such as influenza virus, human metapneumovirus (hMPV), and respiratory syncytial virus (RSV). In a large metropolitan of Thailand’s capital ci...

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Autores principales: Thongpan, Ilada, Suntronwong, Nungruthai, Vichaiwattana, Preeyaporn, Wanlapakorn, Nasamon, Vongpunsawad, Sompong, Poovorawan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462397/
https://www.ncbi.nlm.nih.gov/pubmed/30997293
http://dx.doi.org/10.7717/peerj.6748
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author Thongpan, Ilada
Suntronwong, Nungruthai
Vichaiwattana, Preeyaporn
Wanlapakorn, Nasamon
Vongpunsawad, Sompong
Poovorawan, Yong
author_facet Thongpan, Ilada
Suntronwong, Nungruthai
Vichaiwattana, Preeyaporn
Wanlapakorn, Nasamon
Vongpunsawad, Sompong
Poovorawan, Yong
author_sort Thongpan, Ilada
collection PubMed
description Children and adults residing in densely populated urban centers around the world are at risk of seasonal influenza-like illness caused by respiratory viruses such as influenza virus, human metapneumovirus (hMPV), and respiratory syncytial virus (RSV). In a large metropolitan of Thailand’s capital city Bangkok, most respiratory infections are rarely confirmed by molecular diagnostics. We therefore examined the frequency of RSV, hMPV, and influenza virus in 8,842 patients who presented influenza-like illness and sought medical care at a large hospital in Bangkok between 2016 and 2017. Using a multiplex real-time reverse-transcription polymerase chain reaction (RT-PCR), 30.5% (2,699/8,842) of nasopharyngeal (NP) swab samples tested positive for one or more of these viruses. Influenza virus comprised 17.3% (1,528/8,842), of which the majority were influenza A/H3N2. Such infection was most prevalent among adults and the elderly. RSV was identified in 11.4% (1,011/8,842) and were mostly ON1 and BA9 genotypes. Of the hMPV-positive samples (3.6%, 318/8,842), genotypes A2, B1, and B2 were detected. A small number of individuals experienced co-infections (1.8%, 155/8,842), most commonly between RSV and influenza A/H3N2. RSV and hMPV co-infections were also found, but mainly in young children. Viral respiratory tract infection peaked locally in the rainy season (June to September). These findings support the utility of rapid nucleic acid testing of RSV, hMPV, and influenza virus in patients with ILI.
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spelling pubmed-64623972019-04-17 Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017 Thongpan, Ilada Suntronwong, Nungruthai Vichaiwattana, Preeyaporn Wanlapakorn, Nasamon Vongpunsawad, Sompong Poovorawan, Yong PeerJ Epidemiology Children and adults residing in densely populated urban centers around the world are at risk of seasonal influenza-like illness caused by respiratory viruses such as influenza virus, human metapneumovirus (hMPV), and respiratory syncytial virus (RSV). In a large metropolitan of Thailand’s capital city Bangkok, most respiratory infections are rarely confirmed by molecular diagnostics. We therefore examined the frequency of RSV, hMPV, and influenza virus in 8,842 patients who presented influenza-like illness and sought medical care at a large hospital in Bangkok between 2016 and 2017. Using a multiplex real-time reverse-transcription polymerase chain reaction (RT-PCR), 30.5% (2,699/8,842) of nasopharyngeal (NP) swab samples tested positive for one or more of these viruses. Influenza virus comprised 17.3% (1,528/8,842), of which the majority were influenza A/H3N2. Such infection was most prevalent among adults and the elderly. RSV was identified in 11.4% (1,011/8,842) and were mostly ON1 and BA9 genotypes. Of the hMPV-positive samples (3.6%, 318/8,842), genotypes A2, B1, and B2 were detected. A small number of individuals experienced co-infections (1.8%, 155/8,842), most commonly between RSV and influenza A/H3N2. RSV and hMPV co-infections were also found, but mainly in young children. Viral respiratory tract infection peaked locally in the rainy season (June to September). These findings support the utility of rapid nucleic acid testing of RSV, hMPV, and influenza virus in patients with ILI. PeerJ Inc. 2019-04-11 /pmc/articles/PMC6462397/ /pubmed/30997293 http://dx.doi.org/10.7717/peerj.6748 Text en ©2019 Thongpan et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Epidemiology
Thongpan, Ilada
Suntronwong, Nungruthai
Vichaiwattana, Preeyaporn
Wanlapakorn, Nasamon
Vongpunsawad, Sompong
Poovorawan, Yong
Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017
title Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017
title_full Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017
title_fullStr Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017
title_full_unstemmed Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017
title_short Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017
title_sort respiratory syncytial virus, human metapneumovirus, and influenza virus infection in bangkok, 2016-2017
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462397/
https://www.ncbi.nlm.nih.gov/pubmed/30997293
http://dx.doi.org/10.7717/peerj.6748
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