Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX

We present a rapidly neutralizable and highly anticoagulant thrombin-binding aptamer with a short toehold sequence, originally discovered by systematic evolution of ligands by exponential enrichment (SELEX) with microbead-assisted capillary electrophoresis (MACE). MACE is a novel CE-partitioning met...

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Detalles Bibliográficos
Autores principales: Wakui, Koji, Yoshitomi, Toru, Yamaguchi, Akane, Tsuchida, Maho, Saito, Shingo, Shibukawa, Masami, Furusho, Hitoshi, Yoshimoto, Keitaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462803/
https://www.ncbi.nlm.nih.gov/pubmed/30986696
http://dx.doi.org/10.1016/j.omtn.2019.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462803/
https://www.ncbi.nlm.nih.gov/pubmed/30986696
http://dx.doi.org/10.1016/j.omtn.2019.03.002

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