shRNA‐mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth

The overall survival for patients with primary glioblastoma is very poor. Glioblastoma contains a subpopulation of glioma stem cells (GSC) that are responsible for tumour initiation, treatment resistance and recurrence. PPARα is a transcription factor involved in the control of lipid, carbohydrate a...

Descripción completa

Detalles Bibliográficos
Autores principales: Haynes, Harry R, Scott, Helen L, Killick‐Cole, Clare L, Shaw, Gary, Brend, Tim, Hares, Kelly M, Redondo, Juliana, Kemp, Kevin C, Ballesteros, Lorena S, Herman, Andrew, Cordero‐Llana, Oscar, Singleton, William G, Mills, Francesca, Batstone, Tom, Bulstrode, Harry, Kauppinen, Risto A, Wurdak, Heiko, Uney, James B, Short, Susan C, Wilkins, Alastair, Kurian, Kathreena M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462812/
https://www.ncbi.nlm.nih.gov/pubmed/30565681
http://dx.doi.org/10.1002/path.5201

Ejemplares similares

Ejemplares similares