Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate

AIM: To determine if nonsyndromic cleft lip with or without cleft palate (nsCL/P) genetic risk variants influence liability to nsCL/P through gene regulation pathways, such as those involving DNA methylation. MATERIALS & METHODS: nsCL/P genetic summary data and methylation data from four studies...

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Detalles Bibliográficos
Autores principales: Howe, Laurence J, Richardson, Tom G, Arathimos, Ryan, Alvizi, Lucas, Passos-Bueno, Maria R, Stanier, Philip, Nohr, Ellen, Ludwig, Kerstin U, Mangold, Elisabeth, Knapp, Michael, Stergiakouli, Evie, Pourcain, Beate St, Smith, George Davey, Sandy, Jonathan, Relton, Caroline L, Lewis, Sarah J, Hemani, Gibran, Sharp, Gemma C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462847/
https://www.ncbi.nlm.nih.gov/pubmed/30638414
http://dx.doi.org/10.2217/epi-2018-0091

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