Molecular pathogenesis of disease progression in MLL-rearranged AML

Leukemic relapse is frequently accompanied by progressively aggressive clinical course. To understand the molecular mechanism of leukemic relapse, MLL/AF9-transformed mouse leukemia cells were serially transplanted in C57BL/6 mice (N = 96) by mimicking repeated recurrences, where mutations were moni...

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Detalles Bibliográficos
Autores principales: Kotani, Shinichi, Yoda, Akinori, Kon, Ayana, Kataoka, Keisuke, Ochi, Yotaro, Shiozawa, Yusuke, Hirsch, Cassandra, Takeda, June, Ueno, Hiroo, Yoshizato, Tetsuichi, Yoshida, Kenichi, Nakagawa, Masahiro M., Nannya, Yasuhito, Kakiuchi, Nobuyuki, Yamauchi, Takuji, Aoki, Kosuke, Shiraishi, Yuichi, Miyano, Satoru, Maeda, Takahiro, Maciejewski, Jaroslaw P., Takaori-Kondo, Akifumi, Ogawa, Seishi, Makishima, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462875/
https://www.ncbi.nlm.nih.gov/pubmed/30209403
http://dx.doi.org/10.1038/s41375-018-0253-3

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