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Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria
Predictors for glucose intolerance postpartum were evaluated in women with gestational diabetes mellitus (GDM) based on the 2013 World Health Organization (WHO) criteria. 1841 women were tested for GDM in a prospective cohort study. A postpartum 75g oral glucose tolerance test (OGTT) was performed i...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462976/ https://www.ncbi.nlm.nih.gov/pubmed/30893935 http://dx.doi.org/10.3390/jcm8030383 |
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author | Benhalima, Katrien Van Crombrugge, Paul Moyson, Carolien Verhaeghe, Johan Vandeginste, Sofie Verlaenen, Hilde Vercammen, Chris Maes, Toon Dufraimont, Els De Block, Christophe Jacquemyn, Yves Mekahli, Farah De Clippel, Katrien Van Den Bruel, Annick Loccufier, Anne Laenen, Annouschka Minschart, Caro Devlieger, Roland Mathieu, Chantal |
author_facet | Benhalima, Katrien Van Crombrugge, Paul Moyson, Carolien Verhaeghe, Johan Vandeginste, Sofie Verlaenen, Hilde Vercammen, Chris Maes, Toon Dufraimont, Els De Block, Christophe Jacquemyn, Yves Mekahli, Farah De Clippel, Katrien Van Den Bruel, Annick Loccufier, Anne Laenen, Annouschka Minschart, Caro Devlieger, Roland Mathieu, Chantal |
author_sort | Benhalima, Katrien |
collection | PubMed |
description | Predictors for glucose intolerance postpartum were evaluated in women with gestational diabetes mellitus (GDM) based on the 2013 World Health Organization (WHO) criteria. 1841 women were tested for GDM in a prospective cohort study. A postpartum 75g oral glucose tolerance test (OGTT) was performed in women with GDM at 14 ± 4.1 weeks. Of all 231 mothers with GDM, 83.1% (192) had a postpartum OGTT of which 18.2% (35) had glucose intolerance. Women with glucose intolerance were more often of Asian origin [15.1% vs. 3.7%, OR 4.64 (1.26–17.12)], had more often a recurrent history of GDM [41.7% vs. 26.7%, OR 3.68 (1.37–9.87)], higher fasting glycaemia (FPG) [5.1 (4.5–5.3) vs. 4.6 (4.3–5.1) mmol/L, OR 1.05 (1.01–1.09)], higher HbA1c [33 (31–36) vs. 32 (30–33) mmol/mol, OR 4.89 (1.61–14.82)], and higher triglycerides [2.2 (1.9–2.8) vs. 2.0 (1.6–2.5) mmol/L, OR 1.00 (1.00–1.01)]. Sensitivity of glucose challenge test (GCT) ≥7.2 mmol/l for glucose intolerance postpartum was 80% (63.1%–91.6%). The area under the curve to predict glucose intolerance was 0.76 (0.65–0.87) for FPG, 0.54 (0.43–0.65) for HbA1c and 0.75 (0.64–0.86) for both combined. In conclusion, nearly one-fifth of women with GDM have glucose intolerance postpartum. A GCT ≥7.2 mmol/L identifies a high risk population for glucose intolerance postpartum. |
format | Online Article Text |
id | pubmed-6462976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64629762019-04-19 Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria Benhalima, Katrien Van Crombrugge, Paul Moyson, Carolien Verhaeghe, Johan Vandeginste, Sofie Verlaenen, Hilde Vercammen, Chris Maes, Toon Dufraimont, Els De Block, Christophe Jacquemyn, Yves Mekahli, Farah De Clippel, Katrien Van Den Bruel, Annick Loccufier, Anne Laenen, Annouschka Minschart, Caro Devlieger, Roland Mathieu, Chantal J Clin Med Article Predictors for glucose intolerance postpartum were evaluated in women with gestational diabetes mellitus (GDM) based on the 2013 World Health Organization (WHO) criteria. 1841 women were tested for GDM in a prospective cohort study. A postpartum 75g oral glucose tolerance test (OGTT) was performed in women with GDM at 14 ± 4.1 weeks. Of all 231 mothers with GDM, 83.1% (192) had a postpartum OGTT of which 18.2% (35) had glucose intolerance. Women with glucose intolerance were more often of Asian origin [15.1% vs. 3.7%, OR 4.64 (1.26–17.12)], had more often a recurrent history of GDM [41.7% vs. 26.7%, OR 3.68 (1.37–9.87)], higher fasting glycaemia (FPG) [5.1 (4.5–5.3) vs. 4.6 (4.3–5.1) mmol/L, OR 1.05 (1.01–1.09)], higher HbA1c [33 (31–36) vs. 32 (30–33) mmol/mol, OR 4.89 (1.61–14.82)], and higher triglycerides [2.2 (1.9–2.8) vs. 2.0 (1.6–2.5) mmol/L, OR 1.00 (1.00–1.01)]. Sensitivity of glucose challenge test (GCT) ≥7.2 mmol/l for glucose intolerance postpartum was 80% (63.1%–91.6%). The area under the curve to predict glucose intolerance was 0.76 (0.65–0.87) for FPG, 0.54 (0.43–0.65) for HbA1c and 0.75 (0.64–0.86) for both combined. In conclusion, nearly one-fifth of women with GDM have glucose intolerance postpartum. A GCT ≥7.2 mmol/L identifies a high risk population for glucose intolerance postpartum. MDPI 2019-03-19 /pmc/articles/PMC6462976/ /pubmed/30893935 http://dx.doi.org/10.3390/jcm8030383 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Benhalima, Katrien Van Crombrugge, Paul Moyson, Carolien Verhaeghe, Johan Vandeginste, Sofie Verlaenen, Hilde Vercammen, Chris Maes, Toon Dufraimont, Els De Block, Christophe Jacquemyn, Yves Mekahli, Farah De Clippel, Katrien Van Den Bruel, Annick Loccufier, Anne Laenen, Annouschka Minschart, Caro Devlieger, Roland Mathieu, Chantal Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title | Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_full | Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_fullStr | Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_full_unstemmed | Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_short | Prediction of Glucose Intolerance in Early Postpartum in Women with Gestational Diabetes Mellitus Based on the 2013 WHO Criteria |
title_sort | prediction of glucose intolerance in early postpartum in women with gestational diabetes mellitus based on the 2013 who criteria |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462976/ https://www.ncbi.nlm.nih.gov/pubmed/30893935 http://dx.doi.org/10.3390/jcm8030383 |
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