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VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients

Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in a...

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Autores principales: Jiménez-Sousa, María A., Jiménez, José Luis, Fernández-Rodríguez, Amanda, Brochado-Kith, Oscar, Bellón, José María, Gutierrez, Félix, Díez, Cristina, Bernal-Morell, Enrique, Viciana, Pompeyo, Muñoz-Fernández, María A., Resino, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463017/
https://www.ncbi.nlm.nih.gov/pubmed/30841566
http://dx.doi.org/10.3390/jcm8030311
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author Jiménez-Sousa, María A.
Jiménez, José Luis
Fernández-Rodríguez, Amanda
Brochado-Kith, Oscar
Bellón, José María
Gutierrez, Félix
Díez, Cristina
Bernal-Morell, Enrique
Viciana, Pompeyo
Muñoz-Fernández, María A.
Resino, Salvador
author_facet Jiménez-Sousa, María A.
Jiménez, José Luis
Fernández-Rodríguez, Amanda
Brochado-Kith, Oscar
Bellón, José María
Gutierrez, Félix
Díez, Cristina
Bernal-Morell, Enrique
Viciana, Pompeyo
Muñoz-Fernández, María A.
Resino, Salvador
author_sort Jiménez-Sousa, María A.
collection PubMed
description Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naïve HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience’s MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naïve HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes.
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spelling pubmed-64630172019-04-19 VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients Jiménez-Sousa, María A. Jiménez, José Luis Fernández-Rodríguez, Amanda Brochado-Kith, Oscar Bellón, José María Gutierrez, Félix Díez, Cristina Bernal-Morell, Enrique Viciana, Pompeyo Muñoz-Fernández, María A. Resino, Salvador J Clin Med Brief Report Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naïve HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience’s MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naïve HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes. MDPI 2019-03-05 /pmc/articles/PMC6463017/ /pubmed/30841566 http://dx.doi.org/10.3390/jcm8030311 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Jiménez-Sousa, María A.
Jiménez, José Luis
Fernández-Rodríguez, Amanda
Brochado-Kith, Oscar
Bellón, José María
Gutierrez, Félix
Díez, Cristina
Bernal-Morell, Enrique
Viciana, Pompeyo
Muñoz-Fernández, María A.
Resino, Salvador
VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients
title VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients
title_full VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients
title_fullStr VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients
title_full_unstemmed VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients
title_short VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naïve HIV-Infected Patients
title_sort vdr rs2228570 polymorphism is related to non-progression to aids in antiretroviral therapy naïve hiv-infected patients
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463017/
https://www.ncbi.nlm.nih.gov/pubmed/30841566
http://dx.doi.org/10.3390/jcm8030311
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