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Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study

Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for...

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Autores principales: Runzheimer, Julius, Mewes, Caspar, Büttner, Benedikt, Hinz, José, Popov, Aron-Frederik, Ghadimi, Michael, Kristof, Katalin, Beissbarth, Tim, Schamroth, Joel, Tzvetkov, Mladen, Schmack, Bastian, Quintel, Michael, Bergmann, Ingo, Mansur, Ashham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463065/
https://www.ncbi.nlm.nih.gov/pubmed/30832396
http://dx.doi.org/10.3390/jcm8030301
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author Runzheimer, Julius
Mewes, Caspar
Büttner, Benedikt
Hinz, José
Popov, Aron-Frederik
Ghadimi, Michael
Kristof, Katalin
Beissbarth, Tim
Schamroth, Joel
Tzvetkov, Mladen
Schmack, Bastian
Quintel, Michael
Bergmann, Ingo
Mansur, Ashham
author_facet Runzheimer, Julius
Mewes, Caspar
Büttner, Benedikt
Hinz, José
Popov, Aron-Frederik
Ghadimi, Michael
Kristof, Katalin
Beissbarth, Tim
Schamroth, Joel
Tzvetkov, Mladen
Schmack, Bastian
Quintel, Michael
Bergmann, Ingo
Mansur, Ashham
author_sort Runzheimer, Julius
collection PubMed
description Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for the triggering receptor expressed on myeloid cells 1, which is part of the pro-inflammatory response of the immune system. This study aimed to determine whether the functional TREM-1 rs2234237 single nucleotide polymorphism was associated with mortality in a cohort of 649 Caucasian patients with sepsis. The 90-day mortality rate was the primary outcome, and disease severity and microbiological findings were analyzed as secondary endpoints. TREM-1 rs2234237 TT homozygous patients were compared to A-allele carriers for this purpose. Kaplan–Meier survival analysis revealed no association between the clinically relevant TREM-1 rs2234237 single nucleotide polymorphism and the 90-day or 28-day survival rate in this group of septic patients. In addition, the performed analyses of disease severity and the microbiological findings did not show significant differences between the TREM-1 rs2234237 genotypes. The TREM-1 rs2234237 genotype was not significantly associated with sepsis mortality and sepsis disease severity. Therefore, it was not a valuable prognostic marker for the survival of septic patients in the studied cohort.
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spelling pubmed-64630652019-04-19 Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study Runzheimer, Julius Mewes, Caspar Büttner, Benedikt Hinz, José Popov, Aron-Frederik Ghadimi, Michael Kristof, Katalin Beissbarth, Tim Schamroth, Joel Tzvetkov, Mladen Schmack, Bastian Quintel, Michael Bergmann, Ingo Mansur, Ashham J Clin Med Article Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for the triggering receptor expressed on myeloid cells 1, which is part of the pro-inflammatory response of the immune system. This study aimed to determine whether the functional TREM-1 rs2234237 single nucleotide polymorphism was associated with mortality in a cohort of 649 Caucasian patients with sepsis. The 90-day mortality rate was the primary outcome, and disease severity and microbiological findings were analyzed as secondary endpoints. TREM-1 rs2234237 TT homozygous patients were compared to A-allele carriers for this purpose. Kaplan–Meier survival analysis revealed no association between the clinically relevant TREM-1 rs2234237 single nucleotide polymorphism and the 90-day or 28-day survival rate in this group of septic patients. In addition, the performed analyses of disease severity and the microbiological findings did not show significant differences between the TREM-1 rs2234237 genotypes. The TREM-1 rs2234237 genotype was not significantly associated with sepsis mortality and sepsis disease severity. Therefore, it was not a valuable prognostic marker for the survival of septic patients in the studied cohort. MDPI 2019-03-03 /pmc/articles/PMC6463065/ /pubmed/30832396 http://dx.doi.org/10.3390/jcm8030301 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Runzheimer, Julius
Mewes, Caspar
Büttner, Benedikt
Hinz, José
Popov, Aron-Frederik
Ghadimi, Michael
Kristof, Katalin
Beissbarth, Tim
Schamroth, Joel
Tzvetkov, Mladen
Schmack, Bastian
Quintel, Michael
Bergmann, Ingo
Mansur, Ashham
Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study
title Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study
title_full Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study
title_fullStr Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study
title_full_unstemmed Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study
title_short Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study
title_sort lack of an association between the functional polymorphism trem-1 rs2234237 and the clinical course of sepsis among critically ill caucasian patients—a monocentric prospective genetic association study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463065/
https://www.ncbi.nlm.nih.gov/pubmed/30832396
http://dx.doi.org/10.3390/jcm8030301
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