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Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study
Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463065/ https://www.ncbi.nlm.nih.gov/pubmed/30832396 http://dx.doi.org/10.3390/jcm8030301 |
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author | Runzheimer, Julius Mewes, Caspar Büttner, Benedikt Hinz, José Popov, Aron-Frederik Ghadimi, Michael Kristof, Katalin Beissbarth, Tim Schamroth, Joel Tzvetkov, Mladen Schmack, Bastian Quintel, Michael Bergmann, Ingo Mansur, Ashham |
author_facet | Runzheimer, Julius Mewes, Caspar Büttner, Benedikt Hinz, José Popov, Aron-Frederik Ghadimi, Michael Kristof, Katalin Beissbarth, Tim Schamroth, Joel Tzvetkov, Mladen Schmack, Bastian Quintel, Michael Bergmann, Ingo Mansur, Ashham |
author_sort | Runzheimer, Julius |
collection | PubMed |
description | Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for the triggering receptor expressed on myeloid cells 1, which is part of the pro-inflammatory response of the immune system. This study aimed to determine whether the functional TREM-1 rs2234237 single nucleotide polymorphism was associated with mortality in a cohort of 649 Caucasian patients with sepsis. The 90-day mortality rate was the primary outcome, and disease severity and microbiological findings were analyzed as secondary endpoints. TREM-1 rs2234237 TT homozygous patients were compared to A-allele carriers for this purpose. Kaplan–Meier survival analysis revealed no association between the clinically relevant TREM-1 rs2234237 single nucleotide polymorphism and the 90-day or 28-day survival rate in this group of septic patients. In addition, the performed analyses of disease severity and the microbiological findings did not show significant differences between the TREM-1 rs2234237 genotypes. The TREM-1 rs2234237 genotype was not significantly associated with sepsis mortality and sepsis disease severity. Therefore, it was not a valuable prognostic marker for the survival of septic patients in the studied cohort. |
format | Online Article Text |
id | pubmed-6463065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64630652019-04-19 Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study Runzheimer, Julius Mewes, Caspar Büttner, Benedikt Hinz, José Popov, Aron-Frederik Ghadimi, Michael Kristof, Katalin Beissbarth, Tim Schamroth, Joel Tzvetkov, Mladen Schmack, Bastian Quintel, Michael Bergmann, Ingo Mansur, Ashham J Clin Med Article Sepsis is a life-threatening condition and a significant challenge for those working in intensive care, where it remains one of the leading causes of mortality. According to the sepsis-3 definition, sepsis is characterized by dysregulation of the host response to infection. The TREM-1 gene codes for the triggering receptor expressed on myeloid cells 1, which is part of the pro-inflammatory response of the immune system. This study aimed to determine whether the functional TREM-1 rs2234237 single nucleotide polymorphism was associated with mortality in a cohort of 649 Caucasian patients with sepsis. The 90-day mortality rate was the primary outcome, and disease severity and microbiological findings were analyzed as secondary endpoints. TREM-1 rs2234237 TT homozygous patients were compared to A-allele carriers for this purpose. Kaplan–Meier survival analysis revealed no association between the clinically relevant TREM-1 rs2234237 single nucleotide polymorphism and the 90-day or 28-day survival rate in this group of septic patients. In addition, the performed analyses of disease severity and the microbiological findings did not show significant differences between the TREM-1 rs2234237 genotypes. The TREM-1 rs2234237 genotype was not significantly associated with sepsis mortality and sepsis disease severity. Therefore, it was not a valuable prognostic marker for the survival of septic patients in the studied cohort. MDPI 2019-03-03 /pmc/articles/PMC6463065/ /pubmed/30832396 http://dx.doi.org/10.3390/jcm8030301 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Runzheimer, Julius Mewes, Caspar Büttner, Benedikt Hinz, José Popov, Aron-Frederik Ghadimi, Michael Kristof, Katalin Beissbarth, Tim Schamroth, Joel Tzvetkov, Mladen Schmack, Bastian Quintel, Michael Bergmann, Ingo Mansur, Ashham Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study |
title | Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study |
title_full | Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study |
title_fullStr | Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study |
title_full_unstemmed | Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study |
title_short | Lack of an Association between the Functional Polymorphism TREM-1 rs2234237 and the Clinical Course of Sepsis among Critically Ill Caucasian Patients—A Monocentric Prospective Genetic Association Study |
title_sort | lack of an association between the functional polymorphism trem-1 rs2234237 and the clinical course of sepsis among critically ill caucasian patients—a monocentric prospective genetic association study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463065/ https://www.ncbi.nlm.nih.gov/pubmed/30832396 http://dx.doi.org/10.3390/jcm8030301 |
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