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Immune Response of Galleria mellonella against Human Fungal Pathogens

In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host–pathogen interactions. In recent years, the use of Galleria mellonella larvae, a...

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Autores principales: Trevijano-Contador, Nuria, Zaragoza, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463112/
https://www.ncbi.nlm.nih.gov/pubmed/30587801
http://dx.doi.org/10.3390/jof5010003
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author Trevijano-Contador, Nuria
Zaragoza, Oscar
author_facet Trevijano-Contador, Nuria
Zaragoza, Oscar
author_sort Trevijano-Contador, Nuria
collection PubMed
description In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host–pathogen interactions. In recent years, the use of Galleria mellonella larvae, an insect belonging to the Lepidoptera order, has emerged as an excellent model to study the virulence of human pathogens. It is a model that offers many advantages; for example, it is easy to handle and establish in every laboratory, the larvae have a low cost, and they tolerate a wide range of temperatures, including human temperature 37 °C. The immune response of G. mellonella is innate and is divided into a cellular component (hemocytes) and humoral component (antimicrobial peptides, lytic enzymes, and peptides and melanin) that work together against different intruders. It has been shown that the immune response of this insect has a great specificity and has the ability to distinguish between different classes of microorganisms. In this review, we delve into the different components of the innate immune response of Galleria mellonella, and how these components manifest in the infection of fungal pathogens including Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Histoplasma capsulatum.
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spelling pubmed-64631122019-04-17 Immune Response of Galleria mellonella against Human Fungal Pathogens Trevijano-Contador, Nuria Zaragoza, Oscar J Fungi (Basel) Review In many aspects, the immune response against pathogens in insects is similar to the innate immunity in mammals. This has caused a strong interest in the scientific community for the use of this model in research of host–pathogen interactions. In recent years, the use of Galleria mellonella larvae, an insect belonging to the Lepidoptera order, has emerged as an excellent model to study the virulence of human pathogens. It is a model that offers many advantages; for example, it is easy to handle and establish in every laboratory, the larvae have a low cost, and they tolerate a wide range of temperatures, including human temperature 37 °C. The immune response of G. mellonella is innate and is divided into a cellular component (hemocytes) and humoral component (antimicrobial peptides, lytic enzymes, and peptides and melanin) that work together against different intruders. It has been shown that the immune response of this insect has a great specificity and has the ability to distinguish between different classes of microorganisms. In this review, we delve into the different components of the innate immune response of Galleria mellonella, and how these components manifest in the infection of fungal pathogens including Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Histoplasma capsulatum. MDPI 2018-12-26 /pmc/articles/PMC6463112/ /pubmed/30587801 http://dx.doi.org/10.3390/jof5010003 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Trevijano-Contador, Nuria
Zaragoza, Oscar
Immune Response of Galleria mellonella against Human Fungal Pathogens
title Immune Response of Galleria mellonella against Human Fungal Pathogens
title_full Immune Response of Galleria mellonella against Human Fungal Pathogens
title_fullStr Immune Response of Galleria mellonella against Human Fungal Pathogens
title_full_unstemmed Immune Response of Galleria mellonella against Human Fungal Pathogens
title_short Immune Response of Galleria mellonella against Human Fungal Pathogens
title_sort immune response of galleria mellonella against human fungal pathogens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463112/
https://www.ncbi.nlm.nih.gov/pubmed/30587801
http://dx.doi.org/10.3390/jof5010003
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