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Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study

The background to this study was that factors associated with carcinoid heart disease (CHD) and its impacts on overall survival (OS) are scantly investigated in patients (pts) with neuroendocrine tumors (NETs). In terms of materials and methods, a retrospective multicenter cohort study was conducted...

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Autores principales: Uema, Deise, Alves, Carolina, Mesquita, Marcella, Nuñez, Jose Eduardo, Siepmann, Timo, Angel, Martin, Rego, Juliana F. M., Weschenfelder, Rui, Rocha Filho, Duilio R., Costa, Frederico P., Barros, Milton, O’Connor, Juan M., Illigens, Ben M., Riechelmann, Rachel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463128/
https://www.ncbi.nlm.nih.gov/pubmed/30909590
http://dx.doi.org/10.3390/jcm8030405
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author Uema, Deise
Alves, Carolina
Mesquita, Marcella
Nuñez, Jose Eduardo
Siepmann, Timo
Angel, Martin
Rego, Juliana F. M.
Weschenfelder, Rui
Rocha Filho, Duilio R.
Costa, Frederico P.
Barros, Milton
O’Connor, Juan M.
Illigens, Ben M.
Riechelmann, Rachel P.
author_facet Uema, Deise
Alves, Carolina
Mesquita, Marcella
Nuñez, Jose Eduardo
Siepmann, Timo
Angel, Martin
Rego, Juliana F. M.
Weschenfelder, Rui
Rocha Filho, Duilio R.
Costa, Frederico P.
Barros, Milton
O’Connor, Juan M.
Illigens, Ben M.
Riechelmann, Rachel P.
author_sort Uema, Deise
collection PubMed
description The background to this study was that factors associated with carcinoid heart disease (CHD) and its impacts on overall survival (OS) are scantly investigated in patients (pts) with neuroendocrine tumors (NETs). In terms of materials and methods, a retrospective multicenter cohort study was conducted of factors associated with CHD in advanced NET pts with carcinoid syndrome (CS) and/or elevated urinary 5-hidroxyindole acetic acid (u5HIAA). CHD was defined as at least moderate right valve alterations. The results were the following: Among the 139 subjects included, the majority had a midgut NET (54.2%), 81.3% had CS, and 93% received somatostatin analogues. In a median follow-up of 39 months, 48 (34.5%) pts developed CHD, with a higher frequency in pts treated in public (77.2%) versus private settings (22.9%). In a multivariate logistic regression, unknown primary or colorectal NETs (Odds Ratio (OR) 4.35; p = 0.002), at least 50% liver involvement (OR 3.45; p = 0.005), and being treated in public settings (OR 4.76; p = 0.001) were associated with CHD. In a Cox multivariate regression, bone metastases (Hazard Ratio {HR} 2.8; p = 0.031), CHD (HR 2.63; p = 0.038), and a resection of the primary tumor (HR 0.33; p = 0.026) influenced the risk of death. The conclusions were the following: The incidence of CHD was higher in pts with a high hepatic tumor burden and in those treated in a public system. Delayed diagnosis and limited access to effective therapies negatively affected the lives of NET patients.
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spelling pubmed-64631282019-04-19 Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study Uema, Deise Alves, Carolina Mesquita, Marcella Nuñez, Jose Eduardo Siepmann, Timo Angel, Martin Rego, Juliana F. M. Weschenfelder, Rui Rocha Filho, Duilio R. Costa, Frederico P. Barros, Milton O’Connor, Juan M. Illigens, Ben M. Riechelmann, Rachel P. J Clin Med Article The background to this study was that factors associated with carcinoid heart disease (CHD) and its impacts on overall survival (OS) are scantly investigated in patients (pts) with neuroendocrine tumors (NETs). In terms of materials and methods, a retrospective multicenter cohort study was conducted of factors associated with CHD in advanced NET pts with carcinoid syndrome (CS) and/or elevated urinary 5-hidroxyindole acetic acid (u5HIAA). CHD was defined as at least moderate right valve alterations. The results were the following: Among the 139 subjects included, the majority had a midgut NET (54.2%), 81.3% had CS, and 93% received somatostatin analogues. In a median follow-up of 39 months, 48 (34.5%) pts developed CHD, with a higher frequency in pts treated in public (77.2%) versus private settings (22.9%). In a multivariate logistic regression, unknown primary or colorectal NETs (Odds Ratio (OR) 4.35; p = 0.002), at least 50% liver involvement (OR 3.45; p = 0.005), and being treated in public settings (OR 4.76; p = 0.001) were associated with CHD. In a Cox multivariate regression, bone metastases (Hazard Ratio {HR} 2.8; p = 0.031), CHD (HR 2.63; p = 0.038), and a resection of the primary tumor (HR 0.33; p = 0.026) influenced the risk of death. The conclusions were the following: The incidence of CHD was higher in pts with a high hepatic tumor burden and in those treated in a public system. Delayed diagnosis and limited access to effective therapies negatively affected the lives of NET patients. MDPI 2019-03-23 /pmc/articles/PMC6463128/ /pubmed/30909590 http://dx.doi.org/10.3390/jcm8030405 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Uema, Deise
Alves, Carolina
Mesquita, Marcella
Nuñez, Jose Eduardo
Siepmann, Timo
Angel, Martin
Rego, Juliana F. M.
Weschenfelder, Rui
Rocha Filho, Duilio R.
Costa, Frederico P.
Barros, Milton
O’Connor, Juan M.
Illigens, Ben M.
Riechelmann, Rachel P.
Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study
title Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study
title_full Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study
title_fullStr Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study
title_full_unstemmed Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study
title_short Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study
title_sort carcinoid heart disease and decreased overall survival among patients with neuroendocrine tumors: a retrospective multicenter latin american cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463128/
https://www.ncbi.nlm.nih.gov/pubmed/30909590
http://dx.doi.org/10.3390/jcm8030405
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