MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis

Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique s...

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Autores principales: Melly, Geoff, Purdy, Georgiana E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463170/
https://www.ncbi.nlm.nih.gov/pubmed/30841535
http://dx.doi.org/10.3390/microorganisms7030070
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author Melly, Geoff
Purdy, Georgiana E.
author_facet Melly, Geoff
Purdy, Georgiana E.
author_sort Melly, Geoff
collection PubMed
description Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique structure of the cell envelope and directly support the ability of Mtb to infect and persist in the host. This review summarizes recent investigations that have enabled insight into the molecular mechanisms underlying MmpL substrate export and the role that these substrates play during Mtb infection.
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spelling pubmed-64631702019-04-22 MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis Melly, Geoff Purdy, Georgiana E. Microorganisms Review Mycobacterium tuberculosis (Mtb) remains an important human pathogen. The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity. Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are essential for the unique structure of the cell envelope and directly support the ability of Mtb to infect and persist in the host. This review summarizes recent investigations that have enabled insight into the molecular mechanisms underlying MmpL substrate export and the role that these substrates play during Mtb infection. MDPI 2019-03-05 /pmc/articles/PMC6463170/ /pubmed/30841535 http://dx.doi.org/10.3390/microorganisms7030070 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Melly, Geoff
Purdy, Georgiana E.
MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
title MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
title_full MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
title_fullStr MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
title_full_unstemmed MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
title_short MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis
title_sort mmpl proteins in physiology and pathogenesis of m. tuberculosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463170/
https://www.ncbi.nlm.nih.gov/pubmed/30841535
http://dx.doi.org/10.3390/microorganisms7030070
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