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Fimasartan for Remodeling after Myocardial Infarction
An angiotensin receptor blocker (ARB) mitigates cardiac remodeling after myocardial infarction (MI). Here, we investigated the effect of fimasartan, a new ARB, on cardiac remodeling after MI. Sprague–Dawley rats were assigned into 3 groups: surgery only (sham group, n = 7), MI without (MI-only group...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463200/ https://www.ncbi.nlm.nih.gov/pubmed/30875971 http://dx.doi.org/10.3390/jcm8030366 |
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author | Lim, Byung-Kwan Park, Jin Joo Park, Sung-Ji Lee, You-Jung Kwon, Jin-Sook Kim, Eun-Ji Choi, Dong-Ju |
author_facet | Lim, Byung-Kwan Park, Jin Joo Park, Sung-Ji Lee, You-Jung Kwon, Jin-Sook Kim, Eun-Ji Choi, Dong-Ju |
author_sort | Lim, Byung-Kwan |
collection | PubMed |
description | An angiotensin receptor blocker (ARB) mitigates cardiac remodeling after myocardial infarction (MI). Here, we investigated the effect of fimasartan, a new ARB, on cardiac remodeling after MI. Sprague–Dawley rats were assigned into 3 groups: surgery only (sham group, n = 7), MI without (MI-only group, n = 13), and MI with fimasartan treatment (MI + Fima group, n = 16). MI was induced by the permanent ligation of the left anterior descending artery. Treatment with fimasartan (10 mg/kg) was initiated 24 h after MI and continued for 7 weeks. Rats in the MI + Fima group had a higher mean ejection fraction (66.3 ± 12.5% vs. 51.3 ± 14.8%, P = 0.002) and lower left ventricular end-diastolic diameter (9.14 ± 1.11 mm vs. 9.91 ± 1.43 mm, P = 0.045) than those in the MI-only group at 7 weeks after MI. The infarct size was lower in the MI + Fima than in the MI group (P < 0.05). A microarray analysis revealed that the expression of genes related to the lipid metabolism and mitochondrial membrane ion transporters were upregulated, and those involved in fibrosis and inflammation were downregulated by fimasartan. Fimasartan attenuates cardiac remodeling and dysfunction in rats after MI and may prevent the progression to heart failure after MI. |
format | Online Article Text |
id | pubmed-6463200 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64632002019-04-19 Fimasartan for Remodeling after Myocardial Infarction Lim, Byung-Kwan Park, Jin Joo Park, Sung-Ji Lee, You-Jung Kwon, Jin-Sook Kim, Eun-Ji Choi, Dong-Ju J Clin Med Article An angiotensin receptor blocker (ARB) mitigates cardiac remodeling after myocardial infarction (MI). Here, we investigated the effect of fimasartan, a new ARB, on cardiac remodeling after MI. Sprague–Dawley rats were assigned into 3 groups: surgery only (sham group, n = 7), MI without (MI-only group, n = 13), and MI with fimasartan treatment (MI + Fima group, n = 16). MI was induced by the permanent ligation of the left anterior descending artery. Treatment with fimasartan (10 mg/kg) was initiated 24 h after MI and continued for 7 weeks. Rats in the MI + Fima group had a higher mean ejection fraction (66.3 ± 12.5% vs. 51.3 ± 14.8%, P = 0.002) and lower left ventricular end-diastolic diameter (9.14 ± 1.11 mm vs. 9.91 ± 1.43 mm, P = 0.045) than those in the MI-only group at 7 weeks after MI. The infarct size was lower in the MI + Fima than in the MI group (P < 0.05). A microarray analysis revealed that the expression of genes related to the lipid metabolism and mitochondrial membrane ion transporters were upregulated, and those involved in fibrosis and inflammation were downregulated by fimasartan. Fimasartan attenuates cardiac remodeling and dysfunction in rats after MI and may prevent the progression to heart failure after MI. MDPI 2019-03-15 /pmc/articles/PMC6463200/ /pubmed/30875971 http://dx.doi.org/10.3390/jcm8030366 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lim, Byung-Kwan Park, Jin Joo Park, Sung-Ji Lee, You-Jung Kwon, Jin-Sook Kim, Eun-Ji Choi, Dong-Ju Fimasartan for Remodeling after Myocardial Infarction |
title | Fimasartan for Remodeling after Myocardial Infarction |
title_full | Fimasartan for Remodeling after Myocardial Infarction |
title_fullStr | Fimasartan for Remodeling after Myocardial Infarction |
title_full_unstemmed | Fimasartan for Remodeling after Myocardial Infarction |
title_short | Fimasartan for Remodeling after Myocardial Infarction |
title_sort | fimasartan for remodeling after myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463200/ https://www.ncbi.nlm.nih.gov/pubmed/30875971 http://dx.doi.org/10.3390/jcm8030366 |
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