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Slicing and dicing viruses: antiviral RNA interference in mammals
To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA‐based mechanism,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463209/ https://www.ncbi.nlm.nih.gov/pubmed/30872283 http://dx.doi.org/10.15252/embj.2018100941 |
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author | Maillard, Pierre V van der Veen, Annemarthe G Poirier, Enzo Z Reis e Sousa, Caetano |
author_facet | Maillard, Pierre V van der Veen, Annemarthe G Poirier, Enzo Z Reis e Sousa, Caetano |
author_sort | Maillard, Pierre V |
collection | PubMed |
description | To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA‐based mechanism, for cell‐intrinsic immunity to viruses while vertebrates rely on the protein‐based interferon (IFN)‐driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection. |
format | Online Article Text |
id | pubmed-6463209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64632092019-04-22 Slicing and dicing viruses: antiviral RNA interference in mammals Maillard, Pierre V van der Veen, Annemarthe G Poirier, Enzo Z Reis e Sousa, Caetano EMBO J Review To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA‐based mechanism, for cell‐intrinsic immunity to viruses while vertebrates rely on the protein‐based interferon (IFN)‐driven innate immune system for the same purpose. The RNAi machinery is conserved in vertebrate cells, yet whether antiviral RNAi is still active in mammals and functionally relevant to mammalian antiviral defence is intensely debated. Here, we discuss cellular and viral factors that impact on antiviral RNAi and the contexts in which this system might be at play in mammalian resistance to viral infection. John Wiley and Sons Inc. 2019-03-15 2019-04-15 /pmc/articles/PMC6463209/ /pubmed/30872283 http://dx.doi.org/10.15252/embj.2018100941 Text en © 2019 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Maillard, Pierre V van der Veen, Annemarthe G Poirier, Enzo Z Reis e Sousa, Caetano Slicing and dicing viruses: antiviral RNA interference in mammals |
title | Slicing and dicing viruses: antiviral RNA interference in mammals |
title_full | Slicing and dicing viruses: antiviral RNA interference in mammals |
title_fullStr | Slicing and dicing viruses: antiviral RNA interference in mammals |
title_full_unstemmed | Slicing and dicing viruses: antiviral RNA interference in mammals |
title_short | Slicing and dicing viruses: antiviral RNA interference in mammals |
title_sort | slicing and dicing viruses: antiviral rna interference in mammals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463209/ https://www.ncbi.nlm.nih.gov/pubmed/30872283 http://dx.doi.org/10.15252/embj.2018100941 |
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