Cargando…
Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2
Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult. Small interfering RNAs (siRNAs) are routinely used to selectively silence a target of interest. Owing to the ease of...
Autores principales: | Mihaila, Radu, Ruhela, Dipali, Galinski, Beverly, Card, Ananda, Cancilla, Mark, Shadel, Timothy, Kang, Jing, Tep, Samnang, Wei, Jie, Haas, R. Matthew, Caldwell, Jeremy, Flanagan, W. Michael, Kuklin, Nelly, Cherkaev, Elena, Ason, Brandon |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463220/ https://www.ncbi.nlm.nih.gov/pubmed/30991218 http://dx.doi.org/10.1016/j.omtn.2019.03.004 |
Ejemplares similares
-
Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA
por: Mihaila, Radu, et al.
Publicado: (2017) -
ApoB siRNA-induced Liver Steatosis is Resistant to Clearance by the Loss of Fatty Acid Transport Protein 5 (Fatp5)
por: Ason, Brandon, et al.
Publicado: (2011) -
Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells
por: Vickers, Timothy A., et al.
Publicado: (2007) -
Designing Ago2-specific siRNA/shRNA to Avoid Competition with Endogenous miRNAs
por: Ma, Hongming, et al.
Publicado: (2014) -
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5′-terminal phosphorylation both in vitro and in vivo
por: Kenski, Denise M., et al.
Publicado: (2010)