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High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology
High-Resolution Computed Tomography (HRCT) plays a central role in diagnosing Idiopathic Pulmonary Fibrosis (IPF) while its role in monitoring disease progression is not clearly defined. Given the variable clinical course of the disease, we evaluated whether HRCT abnormalities predict disease behavi...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463252/ https://www.ncbi.nlm.nih.gov/pubmed/30909411 http://dx.doi.org/10.3390/jcm8030399 |
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author | Cocconcelli, Elisabetta Balestro, Elisabetta Biondini, Davide Barbiero, Giulio Polverosi, Roberta Calabrese, Fiorella Pezzuto, Federica Lacedonia, Donato Rea, Federico Schiavon, Marco Bazzan, Erica Foschino Barbaro, Maria Pia Turato, Graziella Spagnolo, Paolo Cosio, Manuel G. Saetta, Marina |
author_facet | Cocconcelli, Elisabetta Balestro, Elisabetta Biondini, Davide Barbiero, Giulio Polverosi, Roberta Calabrese, Fiorella Pezzuto, Federica Lacedonia, Donato Rea, Federico Schiavon, Marco Bazzan, Erica Foschino Barbaro, Maria Pia Turato, Graziella Spagnolo, Paolo Cosio, Manuel G. Saetta, Marina |
author_sort | Cocconcelli, Elisabetta |
collection | PubMed |
description | High-Resolution Computed Tomography (HRCT) plays a central role in diagnosing Idiopathic Pulmonary Fibrosis (IPF) while its role in monitoring disease progression is not clearly defined. Given the variable clinical course of the disease, we evaluated whether HRCT abnormalities predict disease behavior and correlate with functional decline in untreated IPF patients. Forty-nine patients (with HRCT(1)) were functionally categorized as rapid or slow progressors. Twenty-one had a second HRCT(2). Thirteen patients underwent lung transplantation and pathology was quantified. HRCT Alveolar (AS) and Interstitial Scores (IS) were assessed and correlated with Forced Vital Capacity (FVC) decline between HRCT(1) and HRCT(2). At baseline, AS was greater in rapids than in slows, while IS was similar in the two groups. In the 21 subjects with HRCT(2), IS increased over time in both slows and rapids, while AS increased only in rapids. The IS change from HRCT(1) to HRCT(2) normalized per month correlated with FVC decline/month in the whole population, but the change in AS did not. In the 13 patients with pathology, the number of total lymphocytes was higher in rapids than in slows and correlated with AS. Quantitative estimation of HRCTs AS and IS reflects the distinct clinical and pathological behavior of slow and rapid decliners. Furthermore, AS, which reflects the immune/inflammatory infiltrate in lung tissue, could be a useful tool to differentiate rapid from slow progressors at presentation. |
format | Online Article Text |
id | pubmed-6463252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64632522019-04-19 High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology Cocconcelli, Elisabetta Balestro, Elisabetta Biondini, Davide Barbiero, Giulio Polverosi, Roberta Calabrese, Fiorella Pezzuto, Federica Lacedonia, Donato Rea, Federico Schiavon, Marco Bazzan, Erica Foschino Barbaro, Maria Pia Turato, Graziella Spagnolo, Paolo Cosio, Manuel G. Saetta, Marina J Clin Med Article High-Resolution Computed Tomography (HRCT) plays a central role in diagnosing Idiopathic Pulmonary Fibrosis (IPF) while its role in monitoring disease progression is not clearly defined. Given the variable clinical course of the disease, we evaluated whether HRCT abnormalities predict disease behavior and correlate with functional decline in untreated IPF patients. Forty-nine patients (with HRCT(1)) were functionally categorized as rapid or slow progressors. Twenty-one had a second HRCT(2). Thirteen patients underwent lung transplantation and pathology was quantified. HRCT Alveolar (AS) and Interstitial Scores (IS) were assessed and correlated with Forced Vital Capacity (FVC) decline between HRCT(1) and HRCT(2). At baseline, AS was greater in rapids than in slows, while IS was similar in the two groups. In the 21 subjects with HRCT(2), IS increased over time in both slows and rapids, while AS increased only in rapids. The IS change from HRCT(1) to HRCT(2) normalized per month correlated with FVC decline/month in the whole population, but the change in AS did not. In the 13 patients with pathology, the number of total lymphocytes was higher in rapids than in slows and correlated with AS. Quantitative estimation of HRCTs AS and IS reflects the distinct clinical and pathological behavior of slow and rapid decliners. Furthermore, AS, which reflects the immune/inflammatory infiltrate in lung tissue, could be a useful tool to differentiate rapid from slow progressors at presentation. MDPI 2019-03-22 /pmc/articles/PMC6463252/ /pubmed/30909411 http://dx.doi.org/10.3390/jcm8030399 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cocconcelli, Elisabetta Balestro, Elisabetta Biondini, Davide Barbiero, Giulio Polverosi, Roberta Calabrese, Fiorella Pezzuto, Federica Lacedonia, Donato Rea, Federico Schiavon, Marco Bazzan, Erica Foschino Barbaro, Maria Pia Turato, Graziella Spagnolo, Paolo Cosio, Manuel G. Saetta, Marina High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology |
title | High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology |
title_full | High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology |
title_fullStr | High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology |
title_full_unstemmed | High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology |
title_short | High-Resolution Computed Tomography (HRCT) Reflects Disease Progression in Patients with Idiopathic Pulmonary Fibrosis (IPF): Relationship with Lung Pathology |
title_sort | high-resolution computed tomography (hrct) reflects disease progression in patients with idiopathic pulmonary fibrosis (ipf): relationship with lung pathology |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463252/ https://www.ncbi.nlm.nih.gov/pubmed/30909411 http://dx.doi.org/10.3390/jcm8030399 |
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