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The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia

BACKGROUND: The pregnancy pathology preeclampsia is still among the leading causes of ma-ternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the alte...

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Autor principal: Huppertz, Berthold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463401/
https://www.ncbi.nlm.nih.gov/pubmed/29701150
http://dx.doi.org/10.2174/1389201019666180427110547
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author Huppertz, Berthold
author_facet Huppertz, Berthold
author_sort Huppertz, Berthold
collection PubMed
description BACKGROUND: The pregnancy pathology preeclampsia is still among the leading causes of ma-ternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the altered interplay between placenta and mother leading to the clinical symptoms of preeclampsia. However, none of them offers the opportunity to explain the variability of cases with late-onset versus early-onset, mild versus severe and with or with-out additional fetal growth restriction. CONCLUSION: This paper identifies the weaknesses of the most important current hypothesis and at the same time offers a set of new elucidations including maternal susceptibility, and villous/extravillous trophoblast differentiation to explain the development of preeclampsia. Such elucidations allow following new scientific routes and pathways to untangle the etiology of preeclampsia.
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spelling pubmed-64634012019-05-01 The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia Huppertz, Berthold Curr Pharm Biotechnol Article BACKGROUND: The pregnancy pathology preeclampsia is still among the leading causes of ma-ternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the altered interplay between placenta and mother leading to the clinical symptoms of preeclampsia. However, none of them offers the opportunity to explain the variability of cases with late-onset versus early-onset, mild versus severe and with or with-out additional fetal growth restriction. CONCLUSION: This paper identifies the weaknesses of the most important current hypothesis and at the same time offers a set of new elucidations including maternal susceptibility, and villous/extravillous trophoblast differentiation to explain the development of preeclampsia. Such elucidations allow following new scientific routes and pathways to untangle the etiology of preeclampsia. Bentham Science Publishers 2018-08 2018-08 /pmc/articles/PMC6463401/ /pubmed/29701150 http://dx.doi.org/10.2174/1389201019666180427110547 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Huppertz, Berthold
The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
title The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
title_full The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
title_fullStr The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
title_full_unstemmed The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
title_short The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
title_sort critical role of abnormal trophoblast development in the etiology of preeclampsia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463401/
https://www.ncbi.nlm.nih.gov/pubmed/29701150
http://dx.doi.org/10.2174/1389201019666180427110547
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