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The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia
BACKGROUND: The pregnancy pathology preeclampsia is still among the leading causes of ma-ternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the alte...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463401/ https://www.ncbi.nlm.nih.gov/pubmed/29701150 http://dx.doi.org/10.2174/1389201019666180427110547 |
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author | Huppertz, Berthold |
author_facet | Huppertz, Berthold |
author_sort | Huppertz, Berthold |
collection | PubMed |
description | BACKGROUND: The pregnancy pathology preeclampsia is still among the leading causes of ma-ternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the altered interplay between placenta and mother leading to the clinical symptoms of preeclampsia. However, none of them offers the opportunity to explain the variability of cases with late-onset versus early-onset, mild versus severe and with or with-out additional fetal growth restriction. CONCLUSION: This paper identifies the weaknesses of the most important current hypothesis and at the same time offers a set of new elucidations including maternal susceptibility, and villous/extravillous trophoblast differentiation to explain the development of preeclampsia. Such elucidations allow following new scientific routes and pathways to untangle the etiology of preeclampsia. |
format | Online Article Text |
id | pubmed-6463401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-64634012019-05-01 The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia Huppertz, Berthold Curr Pharm Biotechnol Article BACKGROUND: The pregnancy pathology preeclampsia is still among the leading causes of ma-ternal and perinatal morbidity and mortality. At the same time, its etiology is far from being identified and remains obscure in a number of facets. A number of hypotheses have been developed to explain the altered interplay between placenta and mother leading to the clinical symptoms of preeclampsia. However, none of them offers the opportunity to explain the variability of cases with late-onset versus early-onset, mild versus severe and with or with-out additional fetal growth restriction. CONCLUSION: This paper identifies the weaknesses of the most important current hypothesis and at the same time offers a set of new elucidations including maternal susceptibility, and villous/extravillous trophoblast differentiation to explain the development of preeclampsia. Such elucidations allow following new scientific routes and pathways to untangle the etiology of preeclampsia. Bentham Science Publishers 2018-08 2018-08 /pmc/articles/PMC6463401/ /pubmed/29701150 http://dx.doi.org/10.2174/1389201019666180427110547 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Huppertz, Berthold The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia |
title | The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia |
title_full | The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia |
title_fullStr | The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia |
title_full_unstemmed | The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia |
title_short | The Critical Role of Abnormal Trophoblast Development in the Etiology of Preeclampsia |
title_sort | critical role of abnormal trophoblast development in the etiology of preeclampsia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463401/ https://www.ncbi.nlm.nih.gov/pubmed/29701150 http://dx.doi.org/10.2174/1389201019666180427110547 |
work_keys_str_mv | AT huppertzberthold thecriticalroleofabnormaltrophoblastdevelopmentintheetiologyofpreeclampsia AT huppertzberthold criticalroleofabnormaltrophoblastdevelopmentintheetiologyofpreeclampsia |