Cargando…
Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes
OBJECTIVE: To compare the levels of umbilical cord blood Neuron-Specific Enolase (NSE) and troponin T and venous blood gas samples between healthy newborns and growth-retarded fetuses with impaired Doppler velocity or low APGAR scores. MATERIALS AND METHODS: This study was a prospective cohort study...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463424/ https://www.ncbi.nlm.nih.gov/pubmed/31019840 http://dx.doi.org/10.4274/tjod.galenos.2019.84665 |
_version_ | 1783410755404562432 |
---|---|
author | Yakıştıran, Betül Katlan, Doruk Cevdi Yüce, Tuncay Koç, Acar |
author_facet | Yakıştıran, Betül Katlan, Doruk Cevdi Yüce, Tuncay Koç, Acar |
author_sort | Yakıştıran, Betül |
collection | PubMed |
description | OBJECTIVE: To compare the levels of umbilical cord blood Neuron-Specific Enolase (NSE) and troponin T and venous blood gas samples between healthy newborns and growth-retarded fetuses with impaired Doppler velocity or low APGAR scores. MATERIALS AND METHODS: This study was a prospective cohort study. The study group comprised 26 patients with intrauterine growth restriction and pathologic Doppler symptoms, and the control group included 24 healthy fetuses. Umbilical cord blood and blood gas samples were taken from all patients. The blood samples were centrifuged and sent to a laboratory to study NSE and troponin T Perinatal outcomes were evaluated from the medical records of the newborns. RESULTS: Both groups were similar in terms of demographic characteristics. Fetuses with fetal growth restriction (FGR) were born earlier and had lower APGAR scores than the study group. Chronic hypoxemic fetuses in the study group had lower cord pH and HCO(3) levels. Further, troponin T levels were higher in the study group than in the control group. There were no major differences in Doppler velocity measurements. CONCLUSION: It has been understood that cardiac and neuronal injury detection on fetuses with FGR, troponin T, and NSE are indicators that can be used. In the literature there are studies with heterogeneous paradigms using different indicators to find neuronal injury. As a result of this study, it is clear that to assess neonatal prognosis, wider-scoped and comparative studies will provide more information about the subject. |
format | Online Article Text |
id | pubmed-6463424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-64634242019-04-24 Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes Yakıştıran, Betül Katlan, Doruk Cevdi Yüce, Tuncay Koç, Acar Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: To compare the levels of umbilical cord blood Neuron-Specific Enolase (NSE) and troponin T and venous blood gas samples between healthy newborns and growth-retarded fetuses with impaired Doppler velocity or low APGAR scores. MATERIALS AND METHODS: This study was a prospective cohort study. The study group comprised 26 patients with intrauterine growth restriction and pathologic Doppler symptoms, and the control group included 24 healthy fetuses. Umbilical cord blood and blood gas samples were taken from all patients. The blood samples were centrifuged and sent to a laboratory to study NSE and troponin T Perinatal outcomes were evaluated from the medical records of the newborns. RESULTS: Both groups were similar in terms of demographic characteristics. Fetuses with fetal growth restriction (FGR) were born earlier and had lower APGAR scores than the study group. Chronic hypoxemic fetuses in the study group had lower cord pH and HCO(3) levels. Further, troponin T levels were higher in the study group than in the control group. There were no major differences in Doppler velocity measurements. CONCLUSION: It has been understood that cardiac and neuronal injury detection on fetuses with FGR, troponin T, and NSE are indicators that can be used. In the literature there are studies with heterogeneous paradigms using different indicators to find neuronal injury. As a result of this study, it is clear that to assess neonatal prognosis, wider-scoped and comparative studies will provide more information about the subject. Galenos Publishing 2019-03 2019-03-27 /pmc/articles/PMC6463424/ /pubmed/31019840 http://dx.doi.org/10.4274/tjod.galenos.2019.84665 Text en ©Copyright 2019 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Yakıştıran, Betül Katlan, Doruk Cevdi Yüce, Tuncay Koç, Acar Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
title | Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
title_full | Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
title_fullStr | Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
title_full_unstemmed | Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
title_short | Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
title_sort | neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463424/ https://www.ncbi.nlm.nih.gov/pubmed/31019840 http://dx.doi.org/10.4274/tjod.galenos.2019.84665 |
work_keys_str_mv | AT yakıstıranbetul neuralandcardiacinjurymarkersinfetalgrowthrestrictionandtheirrelationtoperinataloutcomes AT katlandorukcevdi neuralandcardiacinjurymarkersinfetalgrowthrestrictionandtheirrelationtoperinataloutcomes AT yucetuncay neuralandcardiacinjurymarkersinfetalgrowthrestrictionandtheirrelationtoperinataloutcomes AT kocacar neuralandcardiacinjurymarkersinfetalgrowthrestrictionandtheirrelationtoperinataloutcomes |