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Cachexia and advanced dementia

Cachexia is a complex metabolic process that is associated with several end‐stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerni...

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Detalles Bibliográficos
Autores principales: Minaglia, Cecilia, Giannotti, Chiara, Boccardi, Virginia, Mecocci, Patrizia, Serafini, Gianluca, Odetti, Patrizio, Monacelli, Fiammetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463474/
https://www.ncbi.nlm.nih.gov/pubmed/30794350
http://dx.doi.org/10.1002/jcsm.12380
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author Minaglia, Cecilia
Giannotti, Chiara
Boccardi, Virginia
Mecocci, Patrizia
Serafini, Gianluca
Odetti, Patrizio
Monacelli, Fiammetta
author_facet Minaglia, Cecilia
Giannotti, Chiara
Boccardi, Virginia
Mecocci, Patrizia
Serafini, Gianluca
Odetti, Patrizio
Monacelli, Fiammetta
author_sort Minaglia, Cecilia
collection PubMed
description Cachexia is a complex metabolic process that is associated with several end‐stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end‐stage dementia.
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spelling pubmed-64634742019-04-22 Cachexia and advanced dementia Minaglia, Cecilia Giannotti, Chiara Boccardi, Virginia Mecocci, Patrizia Serafini, Gianluca Odetti, Patrizio Monacelli, Fiammetta J Cachexia Sarcopenia Muscle Review Cachexia is a complex metabolic process that is associated with several end‐stage organ diseases. It is known to be also associated with advanced dementia, although the pathophysiologic mechanisms are still largely unknown. The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end‐stage dementia. John Wiley and Sons Inc. 2019-02-22 2019-04 /pmc/articles/PMC6463474/ /pubmed/30794350 http://dx.doi.org/10.1002/jcsm.12380 Text en © 2019 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society on Sarcopenia, Cachexia and Wasting Disorders This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review
Minaglia, Cecilia
Giannotti, Chiara
Boccardi, Virginia
Mecocci, Patrizia
Serafini, Gianluca
Odetti, Patrizio
Monacelli, Fiammetta
Cachexia and advanced dementia
title Cachexia and advanced dementia
title_full Cachexia and advanced dementia
title_fullStr Cachexia and advanced dementia
title_full_unstemmed Cachexia and advanced dementia
title_short Cachexia and advanced dementia
title_sort cachexia and advanced dementia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463474/
https://www.ncbi.nlm.nih.gov/pubmed/30794350
http://dx.doi.org/10.1002/jcsm.12380
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