Cargando…
Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children
Wilms' tumor is renal tumor of childhood, characterized by the appearance of embryonic renal tissue and other kidney malformations. The genetic etiology of sporadic Wilms' tumor remains largely unknown. Neurofilament light (NEFL) is a tumor suppressor. We evaluated the association between...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463584/ https://www.ncbi.nlm.nih.gov/pubmed/31057612 http://dx.doi.org/10.1155/2019/3518149 |
_version_ | 1783410779901394944 |
---|---|
author | Jia, Wei Zhu, Jinhong Fu, Wen Zhu, Shibo Deng, Fuming Xia, Huimin Liu, Guo-Chang He, Jing |
author_facet | Jia, Wei Zhu, Jinhong Fu, Wen Zhu, Shibo Deng, Fuming Xia, Huimin Liu, Guo-Chang He, Jing |
author_sort | Jia, Wei |
collection | PubMed |
description | Wilms' tumor is renal tumor of childhood, characterized by the appearance of embryonic renal tissue and other kidney malformations. The genetic etiology of sporadic Wilms' tumor remains largely unknown. Neurofilament light (NEFL) is a tumor suppressor. We evaluated the association between three NEFL gene polymorphisms (rs11994014 G>A, rs2979704 T>C and rs1059111 A>T) and Wilms' tumor susceptibility in a Chinese population consisting of 145 cases and 531 controls. In the single locus analysis, rs2979704 CC variant genotype was associated with a decreased risk of Wilms' tumor [CC vs. TT: adjusted odds ratio (OR)=0.48, 95% confidence interval (CI)=0.24-0.94; CC vs. TT+CT: adjusted OR=0.51, 95% CI=0.27-0.97]. We also observed that carriers of the three protective genotypes had significantly decreased risk of Wilms' tumor when compared to those with 0-2 protective genotypes (adjusted OR=0.49, 95% CI=0.25-0.95). The association between rs11994014 G>A or rs1059111 A>T polymorphisms and Wilms' tumor susceptibility did not reach statistical significance. No significant association was detected in the stratified analyses. Our findings suggested that the NEFL rs2979704 T>C polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population. |
format | Online Article Text |
id | pubmed-6463584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64635842019-05-05 Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children Jia, Wei Zhu, Jinhong Fu, Wen Zhu, Shibo Deng, Fuming Xia, Huimin Liu, Guo-Chang He, Jing J Oncol Research Article Wilms' tumor is renal tumor of childhood, characterized by the appearance of embryonic renal tissue and other kidney malformations. The genetic etiology of sporadic Wilms' tumor remains largely unknown. Neurofilament light (NEFL) is a tumor suppressor. We evaluated the association between three NEFL gene polymorphisms (rs11994014 G>A, rs2979704 T>C and rs1059111 A>T) and Wilms' tumor susceptibility in a Chinese population consisting of 145 cases and 531 controls. In the single locus analysis, rs2979704 CC variant genotype was associated with a decreased risk of Wilms' tumor [CC vs. TT: adjusted odds ratio (OR)=0.48, 95% confidence interval (CI)=0.24-0.94; CC vs. TT+CT: adjusted OR=0.51, 95% CI=0.27-0.97]. We also observed that carriers of the three protective genotypes had significantly decreased risk of Wilms' tumor when compared to those with 0-2 protective genotypes (adjusted OR=0.49, 95% CI=0.25-0.95). The association between rs11994014 G>A or rs1059111 A>T polymorphisms and Wilms' tumor susceptibility did not reach statistical significance. No significant association was detected in the stratified analyses. Our findings suggested that the NEFL rs2979704 T>C polymorphism may be associated with Wilms' tumor susceptibility in the Chinese population. Hindawi 2019-04-01 /pmc/articles/PMC6463584/ /pubmed/31057612 http://dx.doi.org/10.1155/2019/3518149 Text en Copyright © 2019 Wei Jia et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jia, Wei Zhu, Jinhong Fu, Wen Zhu, Shibo Deng, Fuming Xia, Huimin Liu, Guo-Chang He, Jing Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children |
title | Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children |
title_full | Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children |
title_fullStr | Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children |
title_full_unstemmed | Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children |
title_short | Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children |
title_sort | association of nefl gene polymorphisms with wilms' tumor susceptibility in chinese children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463584/ https://www.ncbi.nlm.nih.gov/pubmed/31057612 http://dx.doi.org/10.1155/2019/3518149 |
work_keys_str_mv | AT jiawei associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren AT zhujinhong associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren AT fuwen associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren AT zhushibo associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren AT dengfuming associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren AT xiahuimin associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren AT liuguochang associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren AT hejing associationofneflgenepolymorphismswithwilmstumorsusceptibilityinchinesechildren |