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Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C
BACKGROUND AND OBJECTIVE: Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states. Vitamin D is a powerful immunomodulator and plays a significant role in the inflammatory responses and fibrosis occurring due to hepatitis C virus (HCV) infecti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463826/ https://www.ncbi.nlm.nih.gov/pubmed/30997352 http://dx.doi.org/10.2478/jtim-2019-0004 |
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author | Mohamed, Amal Ahmed Abd Almonaem, Eman R. Mansour, Amira I. Algebaly, HebatAllah Fadel Khattab, Rania Abdelmonem El Abd, Yasmine S. |
author_facet | Mohamed, Amal Ahmed Abd Almonaem, Eman R. Mansour, Amira I. Algebaly, HebatAllah Fadel Khattab, Rania Abdelmonem El Abd, Yasmine S. |
author_sort | Mohamed, Amal Ahmed |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states. Vitamin D is a powerful immunomodulator and plays a significant role in the inflammatory responses and fibrosis occurring due to hepatitis C virus (HCV) infection. This study assessed the level of vitamin D and serum hepcidin and its expression in peripheral blood of children with chronic hepatitis C (CHC) and correlated them with other serum markers to reflect iron metabolism and liver disease severity. METHODS: A total of 100 children were included in this study: 50 with HCV infection and 50 healthy controls. Biochemical parameters together with vitamin D, hepcidin, and its expression were all measured. RESULTS: The level of hepcidin and its expression together with vitamin D and hepcidin-to-ferritin (H/F) ratios were significantly reduced in patients, but the iron and ferritin levels were higher (P<0.001). Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H/F ratio (r = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (r = −0.37). Both hepcidin and ferritin were higher in patients with Child Pugh scores B and C than those with score A (P<0.001). CONCLUSION: Measuring serum hepcidin and its expression together with vitamin D levels in patients may have a prognostic value and is promising in the follow-up of the severity of liver disease. |
format | Online Article Text |
id | pubmed-6463826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-64638262019-04-17 Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C Mohamed, Amal Ahmed Abd Almonaem, Eman R. Mansour, Amira I. Algebaly, HebatAllah Fadel Khattab, Rania Abdelmonem El Abd, Yasmine S. J Transl Int Med Original Article BACKGROUND AND OBJECTIVE: Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states. Vitamin D is a powerful immunomodulator and plays a significant role in the inflammatory responses and fibrosis occurring due to hepatitis C virus (HCV) infection. This study assessed the level of vitamin D and serum hepcidin and its expression in peripheral blood of children with chronic hepatitis C (CHC) and correlated them with other serum markers to reflect iron metabolism and liver disease severity. METHODS: A total of 100 children were included in this study: 50 with HCV infection and 50 healthy controls. Biochemical parameters together with vitamin D, hepcidin, and its expression were all measured. RESULTS: The level of hepcidin and its expression together with vitamin D and hepcidin-to-ferritin (H/F) ratios were significantly reduced in patients, but the iron and ferritin levels were higher (P<0.001). Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H/F ratio (r = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (r = −0.37). Both hepcidin and ferritin were higher in patients with Child Pugh scores B and C than those with score A (P<0.001). CONCLUSION: Measuring serum hepcidin and its expression together with vitamin D levels in patients may have a prognostic value and is promising in the follow-up of the severity of liver disease. Sciendo 2019-03-29 /pmc/articles/PMC6463826/ /pubmed/30997352 http://dx.doi.org/10.2478/jtim-2019-0004 Text en © 2019 Amal Ahmed Mohamed, Eman R. Abd Almonaem, Amira I. Mansour, HebatAllah Fadel Algebaly, Rania Abdelmonem Khattab, Yasmine S. El Abd, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Original Article Mohamed, Amal Ahmed Abd Almonaem, Eman R. Mansour, Amira I. Algebaly, HebatAllah Fadel Khattab, Rania Abdelmonem El Abd, Yasmine S. Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C |
title | Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C |
title_full | Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C |
title_fullStr | Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C |
title_full_unstemmed | Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C |
title_short | Importance of Studying the Levels of Hepcidin and Vitamin D in Egyptian Children with Chronic Hepatitis C |
title_sort | importance of studying the levels of hepcidin and vitamin d in egyptian children with chronic hepatitis c |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463826/ https://www.ncbi.nlm.nih.gov/pubmed/30997352 http://dx.doi.org/10.2478/jtim-2019-0004 |
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