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LncRNA: An All-rounder in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463828/ https://www.ncbi.nlm.nih.gov/pubmed/30997350 http://dx.doi.org/10.2478/jtim-2019-0002 |
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author | Liang, Junyu Chen, Weiqian Lin, Jin |
author_facet | Liang, Junyu Chen, Weiqian Lin, Jin |
author_sort | Liang, Junyu |
collection | PubMed |
description | Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. In addition to working as biomarkers for RA, lncRNAs participate in many specific pathological processes including inflammation, aberrant proliferation, migration, invasion and apoptosis. Further screenings and researches are required to validate the clinical potentials of lncRNAs as diagnostic and therapeutic targets in RA. |
format | Online Article Text |
id | pubmed-6463828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-64638282019-04-17 LncRNA: An All-rounder in Rheumatoid Arthritis Liang, Junyu Chen, Weiqian Lin, Jin J Transl Int Med Review Article Rheumatoid arthritis (RA) is a chronic autoimmune disease and is supposed to have both genetic and environmental backgrounds. Plenty of studies have demonstrated the roles of long non-coding RNAs (lncRNAs) in the initiation and development of RA. Numerous lncRNAs have been found to be dysregulated in RA and to be correlated with disease activity of RA, which indicates potential diagnostic roles of lncRNAs. In addition to working as biomarkers for RA, lncRNAs participate in many specific pathological processes including inflammation, aberrant proliferation, migration, invasion and apoptosis. Further screenings and researches are required to validate the clinical potentials of lncRNAs as diagnostic and therapeutic targets in RA. Sciendo 2019-03-29 /pmc/articles/PMC6463828/ /pubmed/30997350 http://dx.doi.org/10.2478/jtim-2019-0002 Text en © 2019 Junyu Liang, Weiqian Chen, Jin Lin, published by Sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Review Article Liang, Junyu Chen, Weiqian Lin, Jin LncRNA: An All-rounder in Rheumatoid Arthritis |
title | LncRNA: An All-rounder in Rheumatoid Arthritis |
title_full | LncRNA: An All-rounder in Rheumatoid Arthritis |
title_fullStr | LncRNA: An All-rounder in Rheumatoid Arthritis |
title_full_unstemmed | LncRNA: An All-rounder in Rheumatoid Arthritis |
title_short | LncRNA: An All-rounder in Rheumatoid Arthritis |
title_sort | lncrna: an all-rounder in rheumatoid arthritis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463828/ https://www.ncbi.nlm.nih.gov/pubmed/30997350 http://dx.doi.org/10.2478/jtim-2019-0002 |
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