Heterogenous loss of mismatch repair (MMR) protein expression: a challenge for immunohistochemical interpretation and microsatellite instability (MSI) evaluation

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status: being diffusely positive (intact/retained nuclear staining) or showing loss of nuclear tumour staining (MMR protein deficient). Four colonic adenocarcinomas and a gastric adenocarcinoma with associated dysp...

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Detalles Bibliográficos
Autores principales: McCarthy, Aoife J, Capo‐Chichi, Jose‐Mario, Spence, Tara, Grenier, Sylvie, Stockley, Tracy, Kamel‐Reid, Suzanne, Serra, Stefano, Sabatini, Peter, Chetty, Runjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463865/
https://www.ncbi.nlm.nih.gov/pubmed/30387329
http://dx.doi.org/10.1002/cjp2.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463865/
https://www.ncbi.nlm.nih.gov/pubmed/30387329
http://dx.doi.org/10.1002/cjp2.120

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