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An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system

Closed cerebral hemorrhage (CCH) is a common symptom in traumatic brain injury (TBI) patients who suffer intracranial hemorrhage with the dura mater remaining intact. The diagnosis of CCH patients prior to hospitalization and in the early stage of the disease can help patients get earlier treatments...

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Autores principales: Yang, Jun, Zhao, Hui, Li, Gen, Ran, Qisheng, Chen, Jingbo, Bai, Zelin, Jin, Gui, Sun, Jian, Xu, Jia, Qin, Mingxin, Chen, Mingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463870/
https://www.ncbi.nlm.nih.gov/pubmed/30997290
http://dx.doi.org/10.7717/peerj.6717
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author Yang, Jun
Zhao, Hui
Li, Gen
Ran, Qisheng
Chen, Jingbo
Bai, Zelin
Jin, Gui
Sun, Jian
Xu, Jia
Qin, Mingxin
Chen, Mingsheng
author_facet Yang, Jun
Zhao, Hui
Li, Gen
Ran, Qisheng
Chen, Jingbo
Bai, Zelin
Jin, Gui
Sun, Jian
Xu, Jia
Qin, Mingxin
Chen, Mingsheng
author_sort Yang, Jun
collection PubMed
description Closed cerebral hemorrhage (CCH) is a common symptom in traumatic brain injury (TBI) patients who suffer intracranial hemorrhage with the dura mater remaining intact. The diagnosis of CCH patients prior to hospitalization and in the early stage of the disease can help patients get earlier treatments that improve outcomes. In this study, a noncontact, portable system for early TBI-induced CCH detection was constructed that measures the magnetic induction phase shift (MIPS), which is associated with the mean brain conductivity caused by the ratio between the liquid (blood/CSF and the intracranial tissues) change. To evaluate the performance of this system, a rabbit CCH model with two severity levels was established based on the horizontal biological impactor BIM-II, whose feasibility was verified by computed tomography images of three sections and three serial slices. There were two groups involved in the experiments (group 1 with 10 TBI rabbits were simulated by hammer hit with air pressure of 600 kPa by BIM-II and group 2 with 10 TBI rabbits were simulated with 650 kPa). The MIPS values of the two groups were obtained within 30 min before and after injury. In group 1, the MIPS values showed a constant downward trend with a minimum value of −11.17 ± 2.91° at the 30th min after 600 kPa impact by BIM-II. After the 650 kPa impact, the MIPS values in group 2 showed a constant downward trend until the 25th min, with a minimum value of −16.81 ± 2.10°. Unlike group 1, the MIPS values showed an upward trend after that point. Before the injury, the MIPS values in both group 1 and group 2 did not obviously change within the 30 min measurement. Using a support vector machine at the same time point after injury, the classification accuracy of the two types of severity was shown to be beyond 90%. Combined with CCH pathological mechanisms, this system can not only achieve the detection of early functional changes in CCH but can also distinguish different severities of CCH.
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spelling pubmed-64638702019-04-17 An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system Yang, Jun Zhao, Hui Li, Gen Ran, Qisheng Chen, Jingbo Bai, Zelin Jin, Gui Sun, Jian Xu, Jia Qin, Mingxin Chen, Mingsheng PeerJ Bioengineering Closed cerebral hemorrhage (CCH) is a common symptom in traumatic brain injury (TBI) patients who suffer intracranial hemorrhage with the dura mater remaining intact. The diagnosis of CCH patients prior to hospitalization and in the early stage of the disease can help patients get earlier treatments that improve outcomes. In this study, a noncontact, portable system for early TBI-induced CCH detection was constructed that measures the magnetic induction phase shift (MIPS), which is associated with the mean brain conductivity caused by the ratio between the liquid (blood/CSF and the intracranial tissues) change. To evaluate the performance of this system, a rabbit CCH model with two severity levels was established based on the horizontal biological impactor BIM-II, whose feasibility was verified by computed tomography images of three sections and three serial slices. There were two groups involved in the experiments (group 1 with 10 TBI rabbits were simulated by hammer hit with air pressure of 600 kPa by BIM-II and group 2 with 10 TBI rabbits were simulated with 650 kPa). The MIPS values of the two groups were obtained within 30 min before and after injury. In group 1, the MIPS values showed a constant downward trend with a minimum value of −11.17 ± 2.91° at the 30th min after 600 kPa impact by BIM-II. After the 650 kPa impact, the MIPS values in group 2 showed a constant downward trend until the 25th min, with a minimum value of −16.81 ± 2.10°. Unlike group 1, the MIPS values showed an upward trend after that point. Before the injury, the MIPS values in both group 1 and group 2 did not obviously change within the 30 min measurement. Using a support vector machine at the same time point after injury, the classification accuracy of the two types of severity was shown to be beyond 90%. Combined with CCH pathological mechanisms, this system can not only achieve the detection of early functional changes in CCH but can also distinguish different severities of CCH. PeerJ Inc. 2019-04-12 /pmc/articles/PMC6463870/ /pubmed/30997290 http://dx.doi.org/10.7717/peerj.6717 Text en © 2019 Yang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioengineering
Yang, Jun
Zhao, Hui
Li, Gen
Ran, Qisheng
Chen, Jingbo
Bai, Zelin
Jin, Gui
Sun, Jian
Xu, Jia
Qin, Mingxin
Chen, Mingsheng
An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system
title An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system
title_full An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system
title_fullStr An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system
title_full_unstemmed An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system
title_short An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system
title_sort experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system
topic Bioengineering
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463870/
https://www.ncbi.nlm.nih.gov/pubmed/30997290
http://dx.doi.org/10.7717/peerj.6717
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