Naturally presented HLA class I–restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes

Type 1 diabetes (T1D) results from the destruction of pancreatic β-cells by the immune system, and CD8(+) T lymphocytes are critical actors in this autoimmune response. Pancreatic islets are surrounded by a mesh of nervous cells, the peri-insular Schwann cells, which are also targeted by autoreactiv...

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Detalles Bibliográficos
Autores principales: Calviño-Sampedro, Cristina, Gomez-Tourino, Iria, Cordero, Oscar J., Reche, Pedro A., Gómez-Perosanz, Marta, Sánchez-Trincado, Jose Luis, Rodríguez, Miguel Ángel, Sueiro, Aurelio M., Viñuela, Juan E., Calviño, Rubén Varela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463915/
https://www.ncbi.nlm.nih.gov/pubmed/30817223
http://dx.doi.org/10.1096/fj.201802270R

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