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Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients
BACKGROUND: Hospitalisation is associated with adverse health outcomes including loss of muscle strength, muscle mass and functional decline, which might be further aggravated by acute inflammation. This study aimed to determine whether acute inflammation, as denoted by C-reactive protein (CRP), is...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464173/ https://www.ncbi.nlm.nih.gov/pubmed/30986265 http://dx.doi.org/10.1371/journal.pone.0215097 |
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author | Liu, Jessamine Y. J. Reijnierse, Esmee M. van Ancum, Jeanine M. Verlaan, Sjors Meskers, Carel G. M. Maier, Andrea B. |
author_facet | Liu, Jessamine Y. J. Reijnierse, Esmee M. van Ancum, Jeanine M. Verlaan, Sjors Meskers, Carel G. M. Maier, Andrea B. |
author_sort | Liu, Jessamine Y. J. |
collection | PubMed |
description | BACKGROUND: Hospitalisation is associated with adverse health outcomes including loss of muscle strength, muscle mass and functional decline, which might be further aggravated by acute inflammation. This study aimed to determine whether acute inflammation, as denoted by C-reactive protein (CRP), is associated with muscle strength, muscle mass and functional dependency in hospitalised older patients. METHODS: The observational, prospective EMPOWER study included 378 hospitalised patients aged 70 years and older. As part of the hospital assessment, 191 patients (50.5%) had CRP measured. Muscle strength and mass were measured using handheld dynamometry and bioelectrical impedance analysis respectively. Activities of Daily Living (ADL) were assessed using Katz score and Instrumental ADL (IADL) by Lawton and Brody score. Linear regression analyses and logistic regression analyses were performed stratified by sex and adjusted for age and comorbidities. RESULTS: Mean age was 79.7 years (SD 6.4) and 50.8% were males. On admission and discharge, males with elevated CRP had significantly lower handgrip strength and lower absolute muscle mass compared with males with normal CRP and those with no CRP measured. At three months post-discharge, males with elevated CRP were more likely to be ADL dependent than those with normal CRP and with no CRP measured. In females, no associations were found between CRP and muscle strength, muscle mass, ADL or IADL. CONCLUSIONS: Hospitalised older male patients with acute inflammation had lower muscle strength at admission and discharge and lower absolute muscle mass at admission and higher ADL dependency at three months post-discharge. |
format | Online Article Text |
id | pubmed-6464173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64641732019-05-03 Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients Liu, Jessamine Y. J. Reijnierse, Esmee M. van Ancum, Jeanine M. Verlaan, Sjors Meskers, Carel G. M. Maier, Andrea B. PLoS One Research Article BACKGROUND: Hospitalisation is associated with adverse health outcomes including loss of muscle strength, muscle mass and functional decline, which might be further aggravated by acute inflammation. This study aimed to determine whether acute inflammation, as denoted by C-reactive protein (CRP), is associated with muscle strength, muscle mass and functional dependency in hospitalised older patients. METHODS: The observational, prospective EMPOWER study included 378 hospitalised patients aged 70 years and older. As part of the hospital assessment, 191 patients (50.5%) had CRP measured. Muscle strength and mass were measured using handheld dynamometry and bioelectrical impedance analysis respectively. Activities of Daily Living (ADL) were assessed using Katz score and Instrumental ADL (IADL) by Lawton and Brody score. Linear regression analyses and logistic regression analyses were performed stratified by sex and adjusted for age and comorbidities. RESULTS: Mean age was 79.7 years (SD 6.4) and 50.8% were males. On admission and discharge, males with elevated CRP had significantly lower handgrip strength and lower absolute muscle mass compared with males with normal CRP and those with no CRP measured. At three months post-discharge, males with elevated CRP were more likely to be ADL dependent than those with normal CRP and with no CRP measured. In females, no associations were found between CRP and muscle strength, muscle mass, ADL or IADL. CONCLUSIONS: Hospitalised older male patients with acute inflammation had lower muscle strength at admission and discharge and lower absolute muscle mass at admission and higher ADL dependency at three months post-discharge. Public Library of Science 2019-04-15 /pmc/articles/PMC6464173/ /pubmed/30986265 http://dx.doi.org/10.1371/journal.pone.0215097 Text en © 2019 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liu, Jessamine Y. J. Reijnierse, Esmee M. van Ancum, Jeanine M. Verlaan, Sjors Meskers, Carel G. M. Maier, Andrea B. Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients |
title | Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients |
title_full | Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients |
title_fullStr | Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients |
title_full_unstemmed | Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients |
title_short | Acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients |
title_sort | acute inflammation is associated with lower muscle strength, muscle mass and functional dependency in male hospitalised older patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464173/ https://www.ncbi.nlm.nih.gov/pubmed/30986265 http://dx.doi.org/10.1371/journal.pone.0215097 |
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