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Assessment of PD-L1 mRNA and protein expression in non-small cell lung cancer, head and neck squamous cell carcinoma and urothelial carcinoma tissue specimens using RNAScope and immunohistochemistry

Four immunohistochemistry (IHC) diagnostic assays have been approved for tumour PD-L1 protein assessment in the clinic. However, mRNA detection by in situ hybridisation (ISH) could be utilised as an alternative to protein detection. Detecting spatial changes in gene expression provides vital prognos...

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Detalles Bibliográficos
Autores principales:	Duncan, David Jonathan, Scott, Marietta, Scorer, Paul, Barker, Craig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464208/ https://www.ncbi.nlm.nih.gov/pubmed/30986253 http://dx.doi.org/10.1371/journal.pone.0215393

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