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Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates
The transition from adolescence to adulthood is associated with brain remodeling in the final stages of developmental growth. It is also a period when a large proportion of this age group engages in binge alcohol drinking (occasional consumption of four to five drinks leading to intoxication) and he...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464511/ https://www.ncbi.nlm.nih.gov/pubmed/30993181 http://dx.doi.org/10.1523/ENEURO.0044-19.2019 |
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author | Shnitko, Tatiana A. Liu, Zheng Wang, Xiaojie Grant, Kathleen A. Kroenke, Christopher D. |
author_facet | Shnitko, Tatiana A. Liu, Zheng Wang, Xiaojie Grant, Kathleen A. Kroenke, Christopher D. |
author_sort | Shnitko, Tatiana A. |
collection | PubMed |
description | The transition from adolescence to adulthood is associated with brain remodeling in the final stages of developmental growth. It is also a period when a large proportion of this age group engages in binge alcohol drinking (occasional consumption of four to five drinks leading to intoxication) and heavy alcohol drinking (binge drinking on ≥5 d in a month). Here we report on magnetic resonance imaging of developmental changes in the brain occurring during late adolescence and early adulthood (3.5–7.5 years of age) in a rhesus macaque model of alcohol self-administration. Monkeys were imaged prior to alcohol exposure, and following ∼6 and ∼12 months of daily (22 h/d) access to ethanol and water. The results revealed that the brain volume increases by 1 ml/1.87 years throughout the late adolescence and early adulthood in controls. Heavy alcohol drinking reduced the rate of brain growth by 0.25 ml/year per 1 g/kg daily ethanol. Cortical volume increased throughout this period with no significant effect of alcohol drinking on the cortical growth rate. In subcortical regions, age-dependent increases in the volumes of globus pallidus, thalamus, brainstem, and cerebellum were observed. Heavy drinking attenuated the growth rate of the thalamus. Thus, developmental brain volume changes in the span of late adolescence to young adulthood in macaques is altered by excessive alcohol, an insult that may be linked to the continuation of heavy drinking throughout later adult life. |
format | Online Article Text |
id | pubmed-6464511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-64645112019-04-16 Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates Shnitko, Tatiana A. Liu, Zheng Wang, Xiaojie Grant, Kathleen A. Kroenke, Christopher D. eNeuro New Research The transition from adolescence to adulthood is associated with brain remodeling in the final stages of developmental growth. It is also a period when a large proportion of this age group engages in binge alcohol drinking (occasional consumption of four to five drinks leading to intoxication) and heavy alcohol drinking (binge drinking on ≥5 d in a month). Here we report on magnetic resonance imaging of developmental changes in the brain occurring during late adolescence and early adulthood (3.5–7.5 years of age) in a rhesus macaque model of alcohol self-administration. Monkeys were imaged prior to alcohol exposure, and following ∼6 and ∼12 months of daily (22 h/d) access to ethanol and water. The results revealed that the brain volume increases by 1 ml/1.87 years throughout the late adolescence and early adulthood in controls. Heavy alcohol drinking reduced the rate of brain growth by 0.25 ml/year per 1 g/kg daily ethanol. Cortical volume increased throughout this period with no significant effect of alcohol drinking on the cortical growth rate. In subcortical regions, age-dependent increases in the volumes of globus pallidus, thalamus, brainstem, and cerebellum were observed. Heavy drinking attenuated the growth rate of the thalamus. Thus, developmental brain volume changes in the span of late adolescence to young adulthood in macaques is altered by excessive alcohol, an insult that may be linked to the continuation of heavy drinking throughout later adult life. Society for Neuroscience 2019-04-09 /pmc/articles/PMC6464511/ /pubmed/30993181 http://dx.doi.org/10.1523/ENEURO.0044-19.2019 Text en Copyright © 2019 Shnitko et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research Shnitko, Tatiana A. Liu, Zheng Wang, Xiaojie Grant, Kathleen A. Kroenke, Christopher D. Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates |
title | Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates
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title_full | Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates
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title_fullStr | Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates
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title_full_unstemmed | Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates
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title_short | Chronic Alcohol Drinking Slows Brain Development in Adolescent and Young Adult Nonhuman Primates
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title_sort | chronic alcohol drinking slows brain development in adolescent and young adult nonhuman primates |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464511/ https://www.ncbi.nlm.nih.gov/pubmed/30993181 http://dx.doi.org/10.1523/ENEURO.0044-19.2019 |
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