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Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons

Although midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently reported that DA neurons in mice projecting to dorsomedial striatum are modulated by choices contrala...

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Autores principales: Lee, Rachel S, Mattar, Marcelo G, Parker, Nathan F, Witten, Ilana B, Daw, Nathaniel D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464606/
https://www.ncbi.nlm.nih.gov/pubmed/30946008
http://dx.doi.org/10.7554/eLife.42992
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author Lee, Rachel S
Mattar, Marcelo G
Parker, Nathan F
Witten, Ilana B
Daw, Nathaniel D
author_facet Lee, Rachel S
Mattar, Marcelo G
Parker, Nathan F
Witten, Ilana B
Daw, Nathaniel D
author_sort Lee, Rachel S
collection PubMed
description Although midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently reported that DA neurons in mice projecting to dorsomedial striatum are modulated by choices contralateral to the recording side. Here, we introduce, and ultimately reject, a candidate resolution for the puzzling RPE vs movement dichotomy, by showing how seemingly movement-related activity might be explained by an action-specific RPE. By considering both choice and RPE on a trial-by-trial basis, we find that DA signals are modulated by contralateral choice in a manner that is distinct from RPE, implying that choice encoding is better explained by movement direction. This fundamental separation between RPE and movement encoding may help shed light on the diversity of functions and dysfunctions of the DA system.
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spelling pubmed-64646062019-04-17 Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons Lee, Rachel S Mattar, Marcelo G Parker, Nathan F Witten, Ilana B Daw, Nathaniel D eLife Neuroscience Although midbrain dopamine (DA) neurons have been thought to primarily encode reward prediction error (RPE), recent studies have also found movement-related DAergic signals. For example, we recently reported that DA neurons in mice projecting to dorsomedial striatum are modulated by choices contralateral to the recording side. Here, we introduce, and ultimately reject, a candidate resolution for the puzzling RPE vs movement dichotomy, by showing how seemingly movement-related activity might be explained by an action-specific RPE. By considering both choice and RPE on a trial-by-trial basis, we find that DA signals are modulated by contralateral choice in a manner that is distinct from RPE, implying that choice encoding is better explained by movement direction. This fundamental separation between RPE and movement encoding may help shed light on the diversity of functions and dysfunctions of the DA system. eLife Sciences Publications, Ltd 2019-04-04 /pmc/articles/PMC6464606/ /pubmed/30946008 http://dx.doi.org/10.7554/eLife.42992 Text en © 2019, Lee et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Lee, Rachel S
Mattar, Marcelo G
Parker, Nathan F
Witten, Ilana B
Daw, Nathaniel D
Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
title Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
title_full Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
title_fullStr Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
title_full_unstemmed Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
title_short Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons
title_sort reward prediction error does not explain movement selectivity in dms-projecting dopamine neurons
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464606/
https://www.ncbi.nlm.nih.gov/pubmed/30946008
http://dx.doi.org/10.7554/eLife.42992
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