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Hepatitis A immunity in Yozgat, Turkey
BACKGROUND: Since routine immunization could change the epidemiological profile of hepatitis A virus (HAV) infection in the future, it is important to determine the baseline immunity to HAV across Turkey. OBJECTIVE: The aim of this study was to determine the seroprevalence of hepatitis A among indiv...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
King Faisal Specialist Hospital and Research Centre
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464676/ https://www.ncbi.nlm.nih.gov/pubmed/30712049 http://dx.doi.org/10.5144/0256-4947.2019.37 |
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author | Kader, Çiğdem Göçmen, Ayşe Yeşim Demir, Münire Islak Çolak, Nuriye Yalçin Gök, Sebnem Eren Arıkan, Fatma İnci Sara, Mehmet Yıldırım Erbay, Ayse |
author_facet | Kader, Çiğdem Göçmen, Ayşe Yeşim Demir, Münire Islak Çolak, Nuriye Yalçin Gök, Sebnem Eren Arıkan, Fatma İnci Sara, Mehmet Yıldırım Erbay, Ayse |
author_sort | Kader, Çiğdem |
collection | PubMed |
description | BACKGROUND: Since routine immunization could change the epidemiological profile of hepatitis A virus (HAV) infection in the future, it is important to determine the baseline immunity to HAV across Turkey. OBJECTIVE: The aim of this study was to determine the seroprevalence of hepatitis A among individuals 6 years of age and older in Yozgat, Turkey. DESIGN: Cross-sectional. SETTING: Community in central region of Turkey. PATIENTS AND METHODS: Questionnaires and blood specimens were collected and the presence of hepatitis A IgG antibodies against hepatitis A virus was determined quantitatively by ELISA. MAIN OUTCOME MEASURES: The rates of hepatitis A immunity by age group. SAMPLE SIZE: 1862. RESULTS: Immunity to hepatitis A was 79.1% (n=1473). The mean (SD) age was 17.1 (14.7) years in the nonimmune group and 37.8 (19.5) years in the immune group (P<.001), and immunity increased with age. No significant difference in immunity rate was detected between genders in children and adults. The seropositivity rate for subjects ages 6–19 years was lower than in subjects aged 20–96 years (52.2% versus 93.9%; P<.001). CONCLUSION: A catch-up vaccination program is needed for persons aged 6–19 years in Yozgat. LIMITATIONS: Single region data which can not be generalized. For this reason, a multi-centered study that can reflect the whole country is recommended. |
format | Online Article Text |
id | pubmed-6464676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | King Faisal Specialist Hospital and Research Centre |
record_format | MEDLINE/PubMed |
spelling | pubmed-64646762019-04-26 Hepatitis A immunity in Yozgat, Turkey Kader, Çiğdem Göçmen, Ayşe Yeşim Demir, Münire Islak Çolak, Nuriye Yalçin Gök, Sebnem Eren Arıkan, Fatma İnci Sara, Mehmet Yıldırım Erbay, Ayse Ann Saudi Med Original Article BACKGROUND: Since routine immunization could change the epidemiological profile of hepatitis A virus (HAV) infection in the future, it is important to determine the baseline immunity to HAV across Turkey. OBJECTIVE: The aim of this study was to determine the seroprevalence of hepatitis A among individuals 6 years of age and older in Yozgat, Turkey. DESIGN: Cross-sectional. SETTING: Community in central region of Turkey. PATIENTS AND METHODS: Questionnaires and blood specimens were collected and the presence of hepatitis A IgG antibodies against hepatitis A virus was determined quantitatively by ELISA. MAIN OUTCOME MEASURES: The rates of hepatitis A immunity by age group. SAMPLE SIZE: 1862. RESULTS: Immunity to hepatitis A was 79.1% (n=1473). The mean (SD) age was 17.1 (14.7) years in the nonimmune group and 37.8 (19.5) years in the immune group (P<.001), and immunity increased with age. No significant difference in immunity rate was detected between genders in children and adults. The seropositivity rate for subjects ages 6–19 years was lower than in subjects aged 20–96 years (52.2% versus 93.9%; P<.001). CONCLUSION: A catch-up vaccination program is needed for persons aged 6–19 years in Yozgat. LIMITATIONS: Single region data which can not be generalized. For this reason, a multi-centered study that can reflect the whole country is recommended. King Faisal Specialist Hospital and Research Centre 2019 2019-01-31 /pmc/articles/PMC6464676/ /pubmed/30712049 http://dx.doi.org/10.5144/0256-4947.2019.37 Text en Copyright © 2019, Annals of Saudi Medicine This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). The details of which can be accessed at http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Original Article Kader, Çiğdem Göçmen, Ayşe Yeşim Demir, Münire Islak Çolak, Nuriye Yalçin Gök, Sebnem Eren Arıkan, Fatma İnci Sara, Mehmet Yıldırım Erbay, Ayse Hepatitis A immunity in Yozgat, Turkey |
title | Hepatitis A immunity in Yozgat, Turkey |
title_full | Hepatitis A immunity in Yozgat, Turkey |
title_fullStr | Hepatitis A immunity in Yozgat, Turkey |
title_full_unstemmed | Hepatitis A immunity in Yozgat, Turkey |
title_short | Hepatitis A immunity in Yozgat, Turkey |
title_sort | hepatitis a immunity in yozgat, turkey |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464676/ https://www.ncbi.nlm.nih.gov/pubmed/30712049 http://dx.doi.org/10.5144/0256-4947.2019.37 |
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