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Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication

OBJECTIVE: The detection of early gastric cancer (GC) after Helicobacter pylori eradication is expected to increase in Japan. However, the predictive markers for early GC detected after H. pylori eradication have not been extensively studied. We conducted a retrospective, single-center observational...

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Autores principales: Shibukawa, Narihiro, Ouchi, Shohei, Wakamatsu, Shuji, Wakahara, Yuhei, Kaneko, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465014/
https://www.ncbi.nlm.nih.gov/pubmed/30449773
http://dx.doi.org/10.2169/internalmedicine.0925-18
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author Shibukawa, Narihiro
Ouchi, Shohei
Wakamatsu, Shuji
Wakahara, Yuhei
Kaneko, Akira
author_facet Shibukawa, Narihiro
Ouchi, Shohei
Wakamatsu, Shuji
Wakahara, Yuhei
Kaneko, Akira
author_sort Shibukawa, Narihiro
collection PubMed
description OBJECTIVE: The detection of early gastric cancer (GC) after Helicobacter pylori eradication is expected to increase in Japan. However, the predictive markers for early GC detected after H. pylori eradication have not been extensively studied. We conducted a retrospective, single-center observational study to investigate the predictive markers for early GC detected after H. pylori eradiation. METHODS: A total of 421 patients underwent endoscopic submucosal dissection for early GC at NTT West Osaka Hospital between June 2006 and August 2017. Data from patients with GC (Group C; n=70) and without GC (Group NC; n=114) after H. pylori eradication were analyzed. RESULTS: The proportion of men was significantly higher in Group C than in Group NC (92.9% vs. 65.8%; p<0.0001). Complications with other malignant diseases were more prevalent in Group C than in Group NC. A significantly greater proportion of patients had gastric xanthoma (GX) in Group C than in Group NC (64.3% vs. 14.9%; p<0.0001). Regarding scores for endoscopic findings related to the risk of GC, the atrophy score, intestinal metaplasia score and total score were significantly higher in Group C than in Group NC. A multivariate logistic regression analysis identified male sex, atrophy (open type), the presence of intestinal metaplasia and GX as independent predictors for early GC detected after H. pylori eradication. An atrophy-matched control analysis also identified GX as an independent predictor. CONCLUSION: GX is a novel predictive marker for early GC detected after H. pylori eradication.
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spelling pubmed-64650142019-04-16 Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication Shibukawa, Narihiro Ouchi, Shohei Wakamatsu, Shuji Wakahara, Yuhei Kaneko, Akira Intern Med Original Article OBJECTIVE: The detection of early gastric cancer (GC) after Helicobacter pylori eradication is expected to increase in Japan. However, the predictive markers for early GC detected after H. pylori eradication have not been extensively studied. We conducted a retrospective, single-center observational study to investigate the predictive markers for early GC detected after H. pylori eradiation. METHODS: A total of 421 patients underwent endoscopic submucosal dissection for early GC at NTT West Osaka Hospital between June 2006 and August 2017. Data from patients with GC (Group C; n=70) and without GC (Group NC; n=114) after H. pylori eradication were analyzed. RESULTS: The proportion of men was significantly higher in Group C than in Group NC (92.9% vs. 65.8%; p<0.0001). Complications with other malignant diseases were more prevalent in Group C than in Group NC. A significantly greater proportion of patients had gastric xanthoma (GX) in Group C than in Group NC (64.3% vs. 14.9%; p<0.0001). Regarding scores for endoscopic findings related to the risk of GC, the atrophy score, intestinal metaplasia score and total score were significantly higher in Group C than in Group NC. A multivariate logistic regression analysis identified male sex, atrophy (open type), the presence of intestinal metaplasia and GX as independent predictors for early GC detected after H. pylori eradication. An atrophy-matched control analysis also identified GX as an independent predictor. CONCLUSION: GX is a novel predictive marker for early GC detected after H. pylori eradication. The Japanese Society of Internal Medicine 2018-11-19 2019-03-15 /pmc/articles/PMC6465014/ /pubmed/30449773 http://dx.doi.org/10.2169/internalmedicine.0925-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Shibukawa, Narihiro
Ouchi, Shohei
Wakamatsu, Shuji
Wakahara, Yuhei
Kaneko, Akira
Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication
title Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication
title_full Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication
title_fullStr Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication
title_full_unstemmed Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication
title_short Gastric Xanthoma Is a Predictive Marker for Early Gastric Cancer Detected after Helicobacter pylori Eradication
title_sort gastric xanthoma is a predictive marker for early gastric cancer detected after helicobacter pylori eradication
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465014/
https://www.ncbi.nlm.nih.gov/pubmed/30449773
http://dx.doi.org/10.2169/internalmedicine.0925-18
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