ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

Micronuclei represent the cellular attempt to compartmentalize DNA to maintain genomic integrity threatened by mitotic errors and genotoxic events. Some micronuclei show aberrant nuclear envelopes (NEs) that collapse, generating damaged DNA that can promote complex genome alterations. However, ruptu...

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Detalles Bibliográficos
Autores principales: Willan, Jessica, Cleasby, Alexa J., Flores-Rodriguez, Neftali, Stefani, Flavia, Rinaldo, Cinzia, Pisciottani, Alessandra, Grant, Emma, Woodman, Philip, Bryant, Helen E., Ciani, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465242/
https://www.ncbi.nlm.nih.gov/pubmed/30988276
http://dx.doi.org/10.1038/s41389-019-0136-0

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