Repeat domain-associated O-glycans govern PMEL fibrillar sheet architecture

PMEL is a pigment cell-specific protein that forms a functional amyloid matrix in melanosomes. The matrix consists of well-separated fibrillar sheets on which the pigment melanin is deposited. Using electron tomography, we demonstrate that this sheet architecture is governed by the PMEL repeat (RPT)...

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Detalles Bibliográficos
Autores principales: Graham, Morven, Tzika, Athanasia C., Mitchell, Susan M., Liu, Xinran, Leonhardt, Ralf M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465243/
https://www.ncbi.nlm.nih.gov/pubmed/30988362
http://dx.doi.org/10.1038/s41598-019-42571-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465243/
https://www.ncbi.nlm.nih.gov/pubmed/30988362
http://dx.doi.org/10.1038/s41598-019-42571-6

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