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Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle
Compensatory growth (CG) is an accelerated growth phenomenon which occurs in animals upon re-alimentation following a period of dietary restriction. The objective of this study was to perform gene co-expression analysis on metabolic tissues of animals undergoing CG, in order to elucidate the molecul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465245/ https://www.ncbi.nlm.nih.gov/pubmed/30988346 http://dx.doi.org/10.1038/s41598-019-42608-w |
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author | Keogh, Kate Kenny, David A. Waters, Sinead M. |
author_facet | Keogh, Kate Kenny, David A. Waters, Sinead M. |
author_sort | Keogh, Kate |
collection | PubMed |
description | Compensatory growth (CG) is an accelerated growth phenomenon which occurs in animals upon re-alimentation following a period of dietary restriction. The objective of this study was to perform gene co-expression analysis on metabolic tissues of animals undergoing CG, in order to elucidate the molecular control governing this phenomenon. Thirty Holstein Friesian bulls were fed a restricted diet for 125 days, after which they received feed ad libitum. Following 55 days of ad libitum feeding all animals were slaughtered. RNAseq and gene co-expression analyses were performed on tissue samples collected at slaughter including liver, rumen papillae and jejunum epithelium tissues. A period of CG resulted in 15 networks of co-expressed genes. One network of genes, involved in proteasome core complex, signal transduction and protein synthesis was found to be similar across liver and jejunum tissue datasets (r = 0.68, P = 0.04). Results from this study also showed that a large portion of co-expressed genes had not previously been implicated in the expression of CG, thus this study identifies novel genes involved in controlling CG across tissues, with hub genes holding potential for use as biomarkers for the selection of animals with a greater propensity to display CG. |
format | Online Article Text |
id | pubmed-6465245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64652452019-04-18 Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle Keogh, Kate Kenny, David A. Waters, Sinead M. Sci Rep Article Compensatory growth (CG) is an accelerated growth phenomenon which occurs in animals upon re-alimentation following a period of dietary restriction. The objective of this study was to perform gene co-expression analysis on metabolic tissues of animals undergoing CG, in order to elucidate the molecular control governing this phenomenon. Thirty Holstein Friesian bulls were fed a restricted diet for 125 days, after which they received feed ad libitum. Following 55 days of ad libitum feeding all animals were slaughtered. RNAseq and gene co-expression analyses were performed on tissue samples collected at slaughter including liver, rumen papillae and jejunum epithelium tissues. A period of CG resulted in 15 networks of co-expressed genes. One network of genes, involved in proteasome core complex, signal transduction and protein synthesis was found to be similar across liver and jejunum tissue datasets (r = 0.68, P = 0.04). Results from this study also showed that a large portion of co-expressed genes had not previously been implicated in the expression of CG, thus this study identifies novel genes involved in controlling CG across tissues, with hub genes holding potential for use as biomarkers for the selection of animals with a greater propensity to display CG. Nature Publishing Group UK 2019-04-15 /pmc/articles/PMC6465245/ /pubmed/30988346 http://dx.doi.org/10.1038/s41598-019-42608-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Keogh, Kate Kenny, David A. Waters, Sinead M. Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle |
title | Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle |
title_full | Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle |
title_fullStr | Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle |
title_full_unstemmed | Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle |
title_short | Gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle |
title_sort | gene co-expression networks contributing to the expression of compensatory growth in metabolically active tissues in cattle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465245/ https://www.ncbi.nlm.nih.gov/pubmed/30988346 http://dx.doi.org/10.1038/s41598-019-42608-w |
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