Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses

The isolation of human monoclonal antibodies with broadly neutralizing breadth can provide a promising countermeasure for influenza A viruses infection. Most broadly neutralizing antibodies against influenza A viruses bind to the conserved stem region or the receptor-binding cavity of hemagglutinin...

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Detalles Bibliográficos
Autores principales: Xiao, Haixia, Guo, Tianling, Yang, Mi, Qi, Jianxun, Huang, Chaobin, Hong, Yuanyuan, Gu, Jinjin, Pang, Xuefei, Liu, William Jun, Peng, Ruchao, McCauley, John, Bi, Yuhai, Li, Shihua, Feng, Junxia, Zhang, Hailiang, Zhang, Xupei, Lu, Xishan, Yan, Jinghua, Chen, Liling, Shi, Yi, Chen, Weizhi, Gao, George Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465249/
https://www.ncbi.nlm.nih.gov/pubmed/30993000
http://dx.doi.org/10.1038/s41421-019-0086-x

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