c-Jun N-terminal kinase (JNK)-dependent internalization and Rab5-dependent endocytic sorting mediate long-distance retrograde neuronal death induced by axonal BDNF-p75 signaling

During the development of the sympathetic nervous system, signals from tropomyosin-related kinase receptors (Trks) and p75 neurotrophin receptors (p75) compete to regulate survival and connectivity. During this process, nerve growth factor (NGF)- TrkA signaling in axons communicates NGF-mediated tro...

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Detalles Bibliográficos
Autores principales: Escudero, C. A., Cabeza, C., Moya-Alvarado, G., Maloney, M. T., Flores, C. M., Wu, C., Court, F. A., Mobley, W. C., Bronfman, F. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465280/
https://www.ncbi.nlm.nih.gov/pubmed/30988348
http://dx.doi.org/10.1038/s41598-019-42420-6

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