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Mutation-specific peripheral and ER quality control of hERG channel cell-surface expression
Impaired functional plasma membrane (PM) expression of the hERG K(+)-channel is associated with Long-QT syndrome type-2 (LQT2) and increased risk of cardiac arrhythmia. Reduced PM-expression is primarily attributed to retention and degradation of misfolded channels by endoplasmic reticulum (ER) prot...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465299/ https://www.ncbi.nlm.nih.gov/pubmed/30988392 http://dx.doi.org/10.1038/s41598-019-42331-6 |