Cargando…

Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis

Phenotypic changes in lung fibroblasts are believed to contribute to the development of Idiopathic Pulmonary Fibrosis (IPF), a progressive and fatal lung disease. Long intergenic non-coding RNAs (lincRNAs) have been identified as novel regulators of gene expression and protein activity. In non-stimu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hadjicharalambous, Marina R., Roux, Benoit T., Csomor, Eszter, Feghali-Bostwick, Carol A., Murray, Lynne A., Clarke, Deborah L., Lindsay, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465406/ https://www.ncbi.nlm.nih.gov/pubmed/30988425 http://dx.doi.org/10.1038/s41598-019-42292-w

Ejemplares similares

Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts
por: Hadjicharalambous, Marina R., et al.
Publicado: (2018)

Fibroblasts in fibrosis: novel roles and mediators
por: Kendall, Ryan T., et al.
Publicado: (2014)

Idiopathic Pulmonary Fibrosis: Pathogenesis and the Emerging Role of Long Non-Coding RNAs
por: Hadjicharalambous, Marina R., et al.
Publicado: (2020)

Antifibrotic Effects of Roscovitine in Normal and Scleroderma Fibroblasts
por: Steinman, Richard A., et al.
Publicado: (2012)

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis
por: Artlett, Carol M., et al.
Publicado: (2017)

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis
por: Coward, William R., et al.
Publicado: (2014)

The Molecular Mechanisms of Systemic Sclerosis-Associated Lung Fibrosis
por: Mouawad, Joe E., et al.
Publicado: (2023)

The K(+) Channel K(Ca)3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis
por: Roach, Katy Morgan, et al.
Publicado: (2013)

Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is K(Ca)3.1-dependent
por: Roach, Katy M, et al.
Publicado: (2014)

Correction: The K(+) Channel K(Ca)3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis
por: Roach, Katy M, et al.
Publicado: (2014)

Insulin-Like Growth Factor Binding Proteins-3 and -5: Central Mediators of Fibrosis and Promising New Therapeutic Targets
por: Veraldi, Kristen L, et al.
Publicado: (2012)

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
por: Wang, Xiao Mei, et al.
Publicado: (2006)

382 The Role of the IL-6-IGF-II Axis in Systemic Sclerosis-Associated Lung Fibrosis
por: Adewale, Adegboyega Timothy, et al.
Publicado: (2023)

Matrix regulation of idiopathic pulmonary fibrosis: the role of enzymes
por: Clarke, Deborah L, et al.
Publicado: (2013)

The Membrane-Associated Adaptor Protein DOK5 Is Upregulated in Systemic Sclerosis and Associated with IGFBP-5-Induced Fibrosis
por: Yasuoka, Hidekata, et al.
Publicado: (2014)

IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF
por: Su, Yunyun, et al.
Publicado: (2015)

Long Non-Coding RNAs and the Innate Immune Response
por: Hadjicharalambous, Marina R., et al.
Publicado: (2019)

Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5
por: Yamaguchi, Yukie, et al.
Publicado: (2011)

Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2021)

Systems Analysis of Transcriptomic and Proteomic Profiles Identifies Novel Regulation of Fibrotic Programs by miRNAs in Pulmonary Fibrosis Fibroblasts
por: Mullenbrock, Steven, et al.
Publicado: (2018)

PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1
por: Takamura, Naoko, et al.
Publicado: (2021)

First Characterization of the Transcriptome of Lung Fibroblasts of SSc Patients and Healthy Donors of African Ancestry
por: Renaud, Ludivine, et al.
Publicado: (2023)

A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition
por: Watanabe, Tomoya, et al.
Publicado: (2019)

Smoking and Idiopathic Pulmonary Fibrosis
por: Oh, Chad K., et al.
Publicado: (2012)

Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis
por: Renaud, Ludivine, et al.
Publicado: (2020)

IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2018)

Elucidating the cellular mechanism for E2-induced dermal fibrosis
por: Baker Frost, DeAnna, et al.
Publicado: (2021)

Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage
por: Pearson, Mark J., et al.
Publicado: (2016)

Core Promoter Regions of Antisense and Long Intergenic Non-Coding RNAs
por: Savina, Ekaterina A., et al.
Publicado: (2023)

The Role of SOX9 in IGF-II-Mediated Pulmonary Fibrosis
por: Waldrep, Kristy M., et al.
Publicado: (2023)

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
por: Garrett, Sara M., et al.
Publicado: (2019)

Identification and functional annotation of long intergenic non-coding RNAs in Brassicaceae
por: Palos, Kyle, et al.
Publicado: (2022)

Fibroblast Senescence in Idiopathic Pulmonary Fibrosis
por: Lin, Yifan, et al.
Publicado: (2020)

Periostin plays a critical role in the cell cycle in lung fibroblasts
por: Yoshihara, Tomohito, et al.
Publicado: (2020)

The function of non-coding RNAs in idiopathic pulmonary fibrosis
por: Zhang, Hui, et al.
Publicado: (2021)

Functional profiling of long intergenic non-coding RNAs in fission yeast
por: Rodriguez-Lopez, Maria, et al.
Publicado: (2022)

2027 The role of lysyl oxidase in systemic sclerosis-associated lung fibrosis
por: Nguyen, Xinh-Xinh, et al.
Publicado: (2018)

Targeting Alveolar Repair in Idiopathic Pulmonary Fibrosis
por: Ptasinski, Victoria A., et al.
Publicado: (2021)

Genetics of systemic sclerosis: recent advances
por: Ramos, Paula S., et al.
Publicado: (2015)

Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer
por: White, Nicole M, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0bpji2b383uo8uh7d81luh4ii8