Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions

Accumulation of mutated superoxide dismutase 1 (mSOD1) in amyotrophic lateral sclerosis (ALS) involves injury to motor neurons (MNs), activation of glial cells and immune unbalance. However, neuroinflammation, besides its detrimental effects, also plays beneficial roles in ALS pathophysiology. There...

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Detalles Bibliográficos
Autores principales: Vaz, Ana Rita, Pinto, Sara, Ezequiel, Catarina, Cunha, Carolina, Carvalho, Luís A., Moreira, Rui, Brites, Dora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465643/
https://www.ncbi.nlm.nih.gov/pubmed/31024256
http://dx.doi.org/10.3389/fncel.2019.00109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465643/
https://www.ncbi.nlm.nih.gov/pubmed/31024256
http://dx.doi.org/10.3389/fncel.2019.00109

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