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NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans

Natural Killer (NK) cells are potent cytotoxic cells belonging to the family of Innate Lymphoid Cells (ILCs). Their most characterized effector functions are directed to the control of aberrant cells in the body, including both transformed and virus-infected cells. NK cell-mediated recognition of ab...

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Autores principales: Parodi, Monica, Favoreel, Herman, Candiano, Giovanni, Gaggero, Silvia, Sivori, Simona, Mingari, Maria Cristina, Moretta, Lorenzo, Vitale, Massimo, Cantoni, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465645/
https://www.ncbi.nlm.nih.gov/pubmed/31024551
http://dx.doi.org/10.3389/fimmu.2019.00719
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author Parodi, Monica
Favoreel, Herman
Candiano, Giovanni
Gaggero, Silvia
Sivori, Simona
Mingari, Maria Cristina
Moretta, Lorenzo
Vitale, Massimo
Cantoni, Claudia
author_facet Parodi, Monica
Favoreel, Herman
Candiano, Giovanni
Gaggero, Silvia
Sivori, Simona
Mingari, Maria Cristina
Moretta, Lorenzo
Vitale, Massimo
Cantoni, Claudia
author_sort Parodi, Monica
collection PubMed
description Natural Killer (NK) cells are potent cytotoxic cells belonging to the family of Innate Lymphoid Cells (ILCs). Their most characterized effector functions are directed to the control of aberrant cells in the body, including both transformed and virus-infected cells. NK cell-mediated recognition of abnormal cells primarily occurs through receptor-ligand interactions, involving an array of inhibitory and activating NK receptors and different types of ligands expressed on target cells. While most of the receptors have become known over many years, their respective ligands were only defined later and their impressive complexity has only recently become evident. NKp44, a member of Natural Cytotoxicity Receptors (NCRs), is an activating receptor playing a crucial role in most functions exerted by activated NK cells and also by other NKp44(+) immune cells. The large and heterogeneous panel of NKp44 ligands (NKp44L) now includes surface expressed glycoproteins and proteoglycans, nuclear proteins that can be exposed outside the cell, and molecules that can be either released in the extracellular space or carried in extracellular vesicles. Recent findings have extended our knowledge on the nature of NKp44L to soluble plasma glycoproteins, such as secreted growth factors or extracellular matrix (ECM)-derived glycoproteins. NKp44L are induced upon tumor transformation or viral infection but may also be expressed in normal cells and tissues. In addition, NKp44-NKp44L interactions are involved in the crosstalk between NK cells and different innate and adaptive immune cell types. NKp44 expression in different ILCs located in tissues further extends the potential role of NKp44-NKp44L interactions.
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spelling pubmed-64656452019-04-25 NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans Parodi, Monica Favoreel, Herman Candiano, Giovanni Gaggero, Silvia Sivori, Simona Mingari, Maria Cristina Moretta, Lorenzo Vitale, Massimo Cantoni, Claudia Front Immunol Immunology Natural Killer (NK) cells are potent cytotoxic cells belonging to the family of Innate Lymphoid Cells (ILCs). Their most characterized effector functions are directed to the control of aberrant cells in the body, including both transformed and virus-infected cells. NK cell-mediated recognition of abnormal cells primarily occurs through receptor-ligand interactions, involving an array of inhibitory and activating NK receptors and different types of ligands expressed on target cells. While most of the receptors have become known over many years, their respective ligands were only defined later and their impressive complexity has only recently become evident. NKp44, a member of Natural Cytotoxicity Receptors (NCRs), is an activating receptor playing a crucial role in most functions exerted by activated NK cells and also by other NKp44(+) immune cells. The large and heterogeneous panel of NKp44 ligands (NKp44L) now includes surface expressed glycoproteins and proteoglycans, nuclear proteins that can be exposed outside the cell, and molecules that can be either released in the extracellular space or carried in extracellular vesicles. Recent findings have extended our knowledge on the nature of NKp44L to soluble plasma glycoproteins, such as secreted growth factors or extracellular matrix (ECM)-derived glycoproteins. NKp44L are induced upon tumor transformation or viral infection but may also be expressed in normal cells and tissues. In addition, NKp44-NKp44L interactions are involved in the crosstalk between NK cells and different innate and adaptive immune cell types. NKp44 expression in different ILCs located in tissues further extends the potential role of NKp44-NKp44L interactions. Frontiers Media S.A. 2019-04-09 /pmc/articles/PMC6465645/ /pubmed/31024551 http://dx.doi.org/10.3389/fimmu.2019.00719 Text en Copyright © 2019 Parodi, Favoreel, Candiano, Gaggero, Sivori, Mingari, Moretta, Vitale and Cantoni. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Parodi, Monica
Favoreel, Herman
Candiano, Giovanni
Gaggero, Silvia
Sivori, Simona
Mingari, Maria Cristina
Moretta, Lorenzo
Vitale, Massimo
Cantoni, Claudia
NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans
title NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans
title_full NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans
title_fullStr NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans
title_full_unstemmed NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans
title_short NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans
title_sort nkp44-nkp44 ligand interactions in the regulation of natural killer cells and other innate lymphoid cells in humans
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465645/
https://www.ncbi.nlm.nih.gov/pubmed/31024551
http://dx.doi.org/10.3389/fimmu.2019.00719
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