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Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis

BACKGROUND: The relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta‐analysis to obtain a more credible conclusion. METHODS: PubMed, Medline, and Embase were systematic s...

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Autores principales: Chen, Qingfa, Wang, Yu, Xu, Yan, Lin, Hai, Xue, Fangxi, Chen, Xingtian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465661/
https://www.ncbi.nlm.nih.gov/pubmed/30784231
http://dx.doi.org/10.1002/mgg3.589
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author Chen, Qingfa
Wang, Yu
Xu, Yan
Lin, Hai
Xue, Fangxi
Chen, Xingtian
author_facet Chen, Qingfa
Wang, Yu
Xu, Yan
Lin, Hai
Xue, Fangxi
Chen, Xingtian
author_sort Chen, Qingfa
collection PubMed
description BACKGROUND: The relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta‐analysis to obtain a more credible conclusion. METHODS: PubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: A total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72–0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12–1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11–1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74–0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10–1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78–0.98) in overall population. Further subgroup analyses showed that the positive results were mainly driven by the East Asians. However, no positive results were detected in Caucasians and West Asians. CONCLUSION: Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians.
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spelling pubmed-64656612019-04-23 Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis Chen, Qingfa Wang, Yu Xu, Yan Lin, Hai Xue, Fangxi Chen, Xingtian Mol Genet Genomic Med Original Articles BACKGROUND: The relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta‐analysis to obtain a more credible conclusion. METHODS: PubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: A total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72–0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12–1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11–1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74–0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10–1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78–0.98) in overall population. Further subgroup analyses showed that the positive results were mainly driven by the East Asians. However, no positive results were detected in Caucasians and West Asians. CONCLUSION: Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians. John Wiley and Sons Inc. 2019-02-19 /pmc/articles/PMC6465661/ /pubmed/30784231 http://dx.doi.org/10.1002/mgg3.589 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Chen, Qingfa
Wang, Yu
Xu, Yan
Lin, Hai
Xue, Fangxi
Chen, Xingtian
Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis
title Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis
title_full Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis
title_fullStr Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis
title_full_unstemmed Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis
title_short Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis
title_sort correlation between plce1 rs2274223 variant and digestive tract cancer: a meta‐analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465661/
https://www.ncbi.nlm.nih.gov/pubmed/30784231
http://dx.doi.org/10.1002/mgg3.589
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