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Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis
BACKGROUND: The relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta‐analysis to obtain a more credible conclusion. METHODS: PubMed, Medline, and Embase were systematic s...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465661/ https://www.ncbi.nlm.nih.gov/pubmed/30784231 http://dx.doi.org/10.1002/mgg3.589 |
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author | Chen, Qingfa Wang, Yu Xu, Yan Lin, Hai Xue, Fangxi Chen, Xingtian |
author_facet | Chen, Qingfa Wang, Yu Xu, Yan Lin, Hai Xue, Fangxi Chen, Xingtian |
author_sort | Chen, Qingfa |
collection | PubMed |
description | BACKGROUND: The relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta‐analysis to obtain a more credible conclusion. METHODS: PubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: A total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72–0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12–1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11–1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74–0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10–1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78–0.98) in overall population. Further subgroup analyses showed that the positive results were mainly driven by the East Asians. However, no positive results were detected in Caucasians and West Asians. CONCLUSION: Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians. |
format | Online Article Text |
id | pubmed-6465661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64656612019-04-23 Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis Chen, Qingfa Wang, Yu Xu, Yan Lin, Hai Xue, Fangxi Chen, Xingtian Mol Genet Genomic Med Original Articles BACKGROUND: The relationship between phospholipase C ε‐1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta‐analysis to obtain a more credible conclusion. METHODS: PubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS: A total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72–0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12–1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11–1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74–0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10–1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78–0.98) in overall population. Further subgroup analyses showed that the positive results were mainly driven by the East Asians. However, no positive results were detected in Caucasians and West Asians. CONCLUSION: Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians. John Wiley and Sons Inc. 2019-02-19 /pmc/articles/PMC6465661/ /pubmed/30784231 http://dx.doi.org/10.1002/mgg3.589 Text en © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Chen, Qingfa Wang, Yu Xu, Yan Lin, Hai Xue, Fangxi Chen, Xingtian Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis |
title | Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis |
title_full | Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis |
title_fullStr | Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis |
title_full_unstemmed | Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis |
title_short | Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta‐analysis |
title_sort | correlation between plce1 rs2274223 variant and digestive tract cancer: a meta‐analysis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465661/ https://www.ncbi.nlm.nih.gov/pubmed/30784231 http://dx.doi.org/10.1002/mgg3.589 |
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