Importance of Incorporating Protein Flexibility in Molecule Modeling: A Theoretical Study on Type I(1/2) NIK Inhibitors

NF-κB inducing kinase (NIK), which is considered as the central component of the non-canonical NF-κB pathway, has been proved to be an important target for the regulation of the immune system. In the past few years, NIK inhibitors with various scaffolds have been successively reported, among which t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Chao, Liu, Hui, Wang, Xuwen, Lei, Tailong, Wang, Ercheng, Xu, Lei, Yu, Huidong, Li, Dan, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465739/
https://www.ncbi.nlm.nih.gov/pubmed/31024312
http://dx.doi.org/10.3389/fphar.2019.00345

Ejemplares similares

Ejemplares similares