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Chronic functional constipation is strongly linked to vitamin D deficiency

BACKGROUND: Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined. AIM: To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic c...

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Autores principales: Panarese, Alba, Pesce, Francesco, Porcelli, Piero, Riezzo, Giuseppe, Iacovazzi, Palma Aurelia, Leone, Carla Maria, De Carne, Massimo, Rinaldi, Caterina Mammone, Shahini, Endrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465937/
https://www.ncbi.nlm.nih.gov/pubmed/31011257
http://dx.doi.org/10.3748/wjg.v25.i14.1729
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author Panarese, Alba
Pesce, Francesco
Porcelli, Piero
Riezzo, Giuseppe
Iacovazzi, Palma Aurelia
Leone, Carla Maria
De Carne, Massimo
Rinaldi, Caterina Mammone
Shahini, Endrit
author_facet Panarese, Alba
Pesce, Francesco
Porcelli, Piero
Riezzo, Giuseppe
Iacovazzi, Palma Aurelia
Leone, Carla Maria
De Carne, Massimo
Rinaldi, Caterina Mammone
Shahini, Endrit
author_sort Panarese, Alba
collection PubMed
description BACKGROUND: Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined. AIM: To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders. METHODS: We performed a prospective case-control study, from May-June to November 2017. Glucose/lactulose breath tests, radiopaque markers (multiple capsule techniques) and wireless motility capsule analysis were used to assess colonic and oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life (IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14 (HADS-14 A and HADS-14 D). RESULTS: We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels (P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests (IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group (P < 0.001), which significantly correlated with low vitamin D levels (r = - 0.57, P < 0.001; r = 0.21, P = 0.01; r = - 0.48, P < 0.001; r = - 0.57, P < 0.001; r = - 0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder (odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001). CONCLUSION: Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients.
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spelling pubmed-64659372019-04-22 Chronic functional constipation is strongly linked to vitamin D deficiency Panarese, Alba Pesce, Francesco Porcelli, Piero Riezzo, Giuseppe Iacovazzi, Palma Aurelia Leone, Carla Maria De Carne, Massimo Rinaldi, Caterina Mammone Shahini, Endrit World J Gastroenterol Case Control Study BACKGROUND: Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined. AIM: To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders. METHODS: We performed a prospective case-control study, from May-June to November 2017. Glucose/lactulose breath tests, radiopaque markers (multiple capsule techniques) and wireless motility capsule analysis were used to assess colonic and oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life (IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14 (HADS-14 A and HADS-14 D). RESULTS: We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels (P < 0.001), and they showed a significant impairment of all health-related quality of life and psychological tests (IBS-QOL, Short Form Health Survey 12-Physical Component Summary, Short Form Health Survey 12-Mental Component Summary, HADS-14 A and HADS-14 D), as compared to the control group (P < 0.001), which significantly correlated with low vitamin D levels (r = - 0.57, P < 0.001; r = 0.21, P = 0.01; r = - 0.48, P < 0.001; r = - 0.57, P < 0.001; r = - 0.29, P < 0.001, respectively). At multivariate analysis vitamin D low levels remained a significant independent risk factor for the occurrence of intestinal motility disorder (odds ratio = 1.19; 95% confidence interval: 1.14-1.26, P < 0.001). CONCLUSION: Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients. Baishideng Publishing Group Inc 2019-04-14 2019-04-14 /pmc/articles/PMC6465937/ /pubmed/31011257 http://dx.doi.org/10.3748/wjg.v25.i14.1729 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Control Study
Panarese, Alba
Pesce, Francesco
Porcelli, Piero
Riezzo, Giuseppe
Iacovazzi, Palma Aurelia
Leone, Carla Maria
De Carne, Massimo
Rinaldi, Caterina Mammone
Shahini, Endrit
Chronic functional constipation is strongly linked to vitamin D deficiency
title Chronic functional constipation is strongly linked to vitamin D deficiency
title_full Chronic functional constipation is strongly linked to vitamin D deficiency
title_fullStr Chronic functional constipation is strongly linked to vitamin D deficiency
title_full_unstemmed Chronic functional constipation is strongly linked to vitamin D deficiency
title_short Chronic functional constipation is strongly linked to vitamin D deficiency
title_sort chronic functional constipation is strongly linked to vitamin d deficiency
topic Case Control Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465937/
https://www.ncbi.nlm.nih.gov/pubmed/31011257
http://dx.doi.org/10.3748/wjg.v25.i14.1729
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