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Directed in Vitro Evolution of Therapeutic Bacteriophages: The Appelmans Protocol

The ‘Appelmans protocol’ is used by Eastern European researchers to generate therapeutic phages with novel lytic host ranges. Phage cocktails are iteratively grown on a suite of mostly refractory bacterial isolates until the evolved cocktail can lyse the phage-resistant strains. To study this proces...

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Detalles Bibliográficos
Autores principales:	Burrowes, Ben H., Molineux, Ian J., Fralick, Joe A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466182/ https://www.ncbi.nlm.nih.gov/pubmed/30862096 http://dx.doi.org/10.3390/v11030241

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