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Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection

Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a prim...

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Autores principales: Guerra-Maupome, Mariana, Palmer, Mitchell V., McGill, Jodi L., Sacco, Randy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466205/
https://www.ncbi.nlm.nih.gov/pubmed/30626099
http://dx.doi.org/10.3390/vaccines7010007
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author Guerra-Maupome, Mariana
Palmer, Mitchell V.
McGill, Jodi L.
Sacco, Randy E.
author_facet Guerra-Maupome, Mariana
Palmer, Mitchell V.
McGill, Jodi L.
Sacco, Randy E.
author_sort Guerra-Maupome, Mariana
collection PubMed
description Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a primary viral pathogen in cases of pneumonia in young calves and plays a significant role in bovine respiratory disease complex. Importantly, naturally occurring infection of calves with bovine RSV shares many features in common with human RSV infection. Herein, we update our current understanding of RSV infection in cattle, with particular focus on similarities between the calf and human infection, and the recent reports in which the neonatal calf has been employed for the development and testing of vaccines and therapeutics which may be applied to hRSV infection in humans.
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spelling pubmed-64662052019-04-18 Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection Guerra-Maupome, Mariana Palmer, Mitchell V. McGill, Jodi L. Sacco, Randy E. Vaccines (Basel) Review Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a primary viral pathogen in cases of pneumonia in young calves and plays a significant role in bovine respiratory disease complex. Importantly, naturally occurring infection of calves with bovine RSV shares many features in common with human RSV infection. Herein, we update our current understanding of RSV infection in cattle, with particular focus on similarities between the calf and human infection, and the recent reports in which the neonatal calf has been employed for the development and testing of vaccines and therapeutics which may be applied to hRSV infection in humans. MDPI 2019-01-08 /pmc/articles/PMC6466205/ /pubmed/30626099 http://dx.doi.org/10.3390/vaccines7010007 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guerra-Maupome, Mariana
Palmer, Mitchell V.
McGill, Jodi L.
Sacco, Randy E.
Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
title Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
title_full Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
title_fullStr Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
title_full_unstemmed Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
title_short Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
title_sort utility of the neonatal calf model for testing vaccines and intervention strategies for use against human rsv infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466205/
https://www.ncbi.nlm.nih.gov/pubmed/30626099
http://dx.doi.org/10.3390/vaccines7010007
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