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α-Ketoglutaric Acid-Modified Carbonate Apatite Enhances Cellular Uptake and Cytotoxicity of a Raf-Kinase Inhibitor in Breast Cancer Cells through Inhibition of MAPK and PI-3 Kinase Pathways

AZ628 is a hydrophobic Raf-kinase inhibitor (rapidly accelerated fibrosarcoma) currently in clinical trial of various cancer. The physicochemical properties of hydrophobic drugs that affect the drug-particle interactions and cause aggregation of drugs and particles might be the key aspect to impede...

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Detalles Bibliográficos
Autores principales:	Hossain, Sultana Mehbuba, Shetty, Jayalaxmi, Tha, Kyi Kyi, Chowdhury, Ezharul Hoque
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466362/ https://www.ncbi.nlm.nih.gov/pubmed/30609867 http://dx.doi.org/10.3390/biomedicines7010004

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