Inclusion of Antibodies to Cell Culture Media Preserves the Integrity of Genes Encoding RL13 and the Pentameric Complex Components During Fibroblast Passage of Human Cytomegalovirus

Propagation of human cytomegalovirus (CMV) in cultured cells results in genetic adaptations that confer improved growth in vitro and significant attenuation in vivo. Mutations in RL13 arise quickly, while mutations in the UL128-131A locus emerge later during fibroblast passage and disrupt formation...

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Detalles Bibliográficos
Autores principales: Ourahmane, Amine, Cui, Xiaohong, He, Li, Catron, Meaghan, Dittmer, Dirk P., Al Qaffasaa, Ahmed, Schleiss, Mark R., Hertel, Laura, McVoy, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466449/
https://www.ncbi.nlm.nih.gov/pubmed/30841507
http://dx.doi.org/10.3390/v11030221

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