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Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria

Orbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels. The aim of this study was to evaluate the fixed almond oil physicochemical characterizati...

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Autores principales: Machado, Jean Ferreira, do Socorro Costa, Maria, Tintino, Saulo Relison, Rodrigues, Fábio Fernandes Galvão, Nobre, Camila Bezerra, Coutinho, Henrique Douglas Melo, da Costa, José Galberto Martins, de Menezes, Irwin Rose Alencar, de Sousa, Erlânio Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466557/
https://www.ncbi.nlm.nih.gov/pubmed/30884871
http://dx.doi.org/10.3390/antibiotics8010028
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author Machado, Jean Ferreira
do Socorro Costa, Maria
Tintino, Saulo Relison
Rodrigues, Fábio Fernandes Galvão
Nobre, Camila Bezerra
Coutinho, Henrique Douglas Melo
da Costa, José Galberto Martins
de Menezes, Irwin Rose Alencar
de Sousa, Erlânio Oliveira
author_facet Machado, Jean Ferreira
do Socorro Costa, Maria
Tintino, Saulo Relison
Rodrigues, Fábio Fernandes Galvão
Nobre, Camila Bezerra
Coutinho, Henrique Douglas Melo
da Costa, José Galberto Martins
de Menezes, Irwin Rose Alencar
de Sousa, Erlânio Oliveira
author_sort Machado, Jean Ferreira
collection PubMed
description Orbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels. The aim of this study was to evaluate the fixed almond oil physicochemical characterization and its antibacterial activity in isolation and in association with aminoglycosides against standard and multidrug-resistant bacteria. Analyses such as water content, pH, acidity, peroxide index, relative density, and refractive index indicate the stability and chemical quality of the oil. In the oil’s GC/MS chemical composition analysis, a high saturated fatty acid (76.90%) content was observed. Lauric acid (56.28%) and oleic acid (23.10%) were the major oil components. In the antibacterial test, a more significant oil activity was observed against K. pneumoniae KP-ATCC 10031 (minimal inhibitory concentration (MIC) = 406.37 μg/mL) and Staphylococcus aureus ATCC 6538 (MIC = 812.75 μg/mL), but for the other strains—including standard and multi-resistant strains—the oil presented an MIC ≥ 1024 μg/mL. Furthermore, a synergistic effect was observed when the oil was associated with amikacin and gentamicin against S. aureus (SA-10) and an antagonistic effect was observed with amikacin against Escherichia coli. Data indicate the O. speciosa oil as a valuable nutritional source of lauric, oleic, and myristic fatty acids with an ability to modulate aminoglycoside activity.
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spelling pubmed-64665572019-04-18 Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria Machado, Jean Ferreira do Socorro Costa, Maria Tintino, Saulo Relison Rodrigues, Fábio Fernandes Galvão Nobre, Camila Bezerra Coutinho, Henrique Douglas Melo da Costa, José Galberto Martins de Menezes, Irwin Rose Alencar de Sousa, Erlânio Oliveira Antibiotics (Basel) Article Orbignya speciosa (babassu) is an important palm tree in Brazil whose fixed almond oil is used in popular medicine and especially in food, in addition to being a research target for the manufacture of biofuels. The aim of this study was to evaluate the fixed almond oil physicochemical characterization and its antibacterial activity in isolation and in association with aminoglycosides against standard and multidrug-resistant bacteria. Analyses such as water content, pH, acidity, peroxide index, relative density, and refractive index indicate the stability and chemical quality of the oil. In the oil’s GC/MS chemical composition analysis, a high saturated fatty acid (76.90%) content was observed. Lauric acid (56.28%) and oleic acid (23.10%) were the major oil components. In the antibacterial test, a more significant oil activity was observed against K. pneumoniae KP-ATCC 10031 (minimal inhibitory concentration (MIC) = 406.37 μg/mL) and Staphylococcus aureus ATCC 6538 (MIC = 812.75 μg/mL), but for the other strains—including standard and multi-resistant strains—the oil presented an MIC ≥ 1024 μg/mL. Furthermore, a synergistic effect was observed when the oil was associated with amikacin and gentamicin against S. aureus (SA-10) and an antagonistic effect was observed with amikacin against Escherichia coli. Data indicate the O. speciosa oil as a valuable nutritional source of lauric, oleic, and myristic fatty acids with an ability to modulate aminoglycoside activity. MDPI 2019-03-17 /pmc/articles/PMC6466557/ /pubmed/30884871 http://dx.doi.org/10.3390/antibiotics8010028 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Machado, Jean Ferreira
do Socorro Costa, Maria
Tintino, Saulo Relison
Rodrigues, Fábio Fernandes Galvão
Nobre, Camila Bezerra
Coutinho, Henrique Douglas Melo
da Costa, José Galberto Martins
de Menezes, Irwin Rose Alencar
de Sousa, Erlânio Oliveira
Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria
title Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria
title_full Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria
title_fullStr Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria
title_full_unstemmed Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria
title_short Antibiotic Activity Potentiation and Physicochemical Characterization of the Fixed Orbignya speciosa Almond Oil against MDR Staphylococcus aureus and Other Bacteria
title_sort antibiotic activity potentiation and physicochemical characterization of the fixed orbignya speciosa almond oil against mdr staphylococcus aureus and other bacteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466557/
https://www.ncbi.nlm.nih.gov/pubmed/30884871
http://dx.doi.org/10.3390/antibiotics8010028
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