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Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs

BACKGROUND: Accumulating evidence suggests that epigenetic changes play key roles in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the dynamic regulation of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in diabetic peripheral blood DNA remains to be elucidated. RESULTS: W...

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Detalles Bibliográficos
Autores principales:	Yuan, Er-Feng, Yang, Ying, Cheng, Lin, Deng, Xujing, Chen, Shao-Min, Zhou, Xin, Liu, Song-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466651/ https://www.ncbi.nlm.nih.gov/pubmed/30987683 http://dx.doi.org/10.1186/s13148-019-0660-y

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